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Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions

The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Thoug...

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Autores principales: Bazard, Parveen, Pineros, Jennifer, Frisina, Robert D., Bauer, Mark A., Acosta, Alejandro A., Paganella, Lauren R., Borakiewicz, Dominika, Thivierge, Mark, Mannering, Freyda L., Zhu, Xiaoxia, Ding, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534887/
https://www.ncbi.nlm.nih.gov/pubmed/34685743
http://dx.doi.org/10.3390/cells10102761
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author Bazard, Parveen
Pineros, Jennifer
Frisina, Robert D.
Bauer, Mark A.
Acosta, Alejandro A.
Paganella, Lauren R.
Borakiewicz, Dominika
Thivierge, Mark
Mannering, Freyda L.
Zhu, Xiaoxia
Ding, Bo
author_facet Bazard, Parveen
Pineros, Jennifer
Frisina, Robert D.
Bauer, Mark A.
Acosta, Alejandro A.
Paganella, Lauren R.
Borakiewicz, Dominika
Thivierge, Mark
Mannering, Freyda L.
Zhu, Xiaoxia
Ding, Bo
author_sort Bazard, Parveen
collection PubMed
description The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.
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spelling pubmed-85348872021-10-23 Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions Bazard, Parveen Pineros, Jennifer Frisina, Robert D. Bauer, Mark A. Acosta, Alejandro A. Paganella, Lauren R. Borakiewicz, Dominika Thivierge, Mark Mannering, Freyda L. Zhu, Xiaoxia Ding, Bo Cells Review The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age. MDPI 2021-10-15 /pmc/articles/PMC8534887/ /pubmed/34685743 http://dx.doi.org/10.3390/cells10102761 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bazard, Parveen
Pineros, Jennifer
Frisina, Robert D.
Bauer, Mark A.
Acosta, Alejandro A.
Paganella, Lauren R.
Borakiewicz, Dominika
Thivierge, Mark
Mannering, Freyda L.
Zhu, Xiaoxia
Ding, Bo
Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title_full Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title_fullStr Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title_full_unstemmed Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title_short Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
title_sort cochlear inflammaging in relation to ion channels and mitochondrial functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534887/
https://www.ncbi.nlm.nih.gov/pubmed/34685743
http://dx.doi.org/10.3390/cells10102761
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