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Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study
(1) Background: Preterm birth exposes the infant to the known risk factors for atopic diseases. We aimed to study the neonatal risk factors and to describe the clinical manifestations of atopy, including the march of symptoms, in a cohort of preschool children born preterm. (2) Methods: We enrolled...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534898/ https://www.ncbi.nlm.nih.gov/pubmed/34682108 http://dx.doi.org/10.3390/children8100843 |
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author | Pagano, Federica Conti, Maria Giulia Boscarino, Giovanni Pannucci, Chiara Dito, Lucia Regoli, Daniela Di Chiara, Maria Battaglia, Giuseppe Prota, Rita Cinicola, Bianca Zicari, Anna Maria Aloi, Marina Oliva, Salvatore Terrin, Gianluca |
author_facet | Pagano, Federica Conti, Maria Giulia Boscarino, Giovanni Pannucci, Chiara Dito, Lucia Regoli, Daniela Di Chiara, Maria Battaglia, Giuseppe Prota, Rita Cinicola, Bianca Zicari, Anna Maria Aloi, Marina Oliva, Salvatore Terrin, Gianluca |
author_sort | Pagano, Federica |
collection | PubMed |
description | (1) Background: Preterm birth exposes the infant to the known risk factors for atopic diseases. We aimed to study the neonatal risk factors and to describe the clinical manifestations of atopy, including the march of symptoms, in a cohort of preschool children born preterm. (2) Methods: We enrolled neonates with gestational age < 32 weeks or birth weight < 1500 g. We classified patients in cases and controls according to the presence of at least one atopic manifestation. (3) Results: We observed 72 cases and 93 controls. Multivariate models showed that the administration of more than one cycle of antibiotics (B 0.902, p = 0.026) and gestational diabetes (B 1.207, p = 0.035) influence the risk of atopy in babies born preterm. In addition, risk of atopic dermatitis was influenced by gestational age < 29 weeks (B −1.710, p = 0.025) and gestational diabetes (B 1.275, p = 0.027). The risk of wheeze was associated with familiarity for asthma (B 1.392, p = 0.022) and the administration of more than one cycle of antibiotics (B 0.969, p = 0.025). We observed a significant reduction in the rate of atopic manifestation after 2 years of life (33.9% vs. 23.8%, p < 0.05). (4) Conclusions: Modifiable (gestational diabetes, antibiotics use) and unmodifiable (familiarity for asthma) conditions influence the risk of atopy in babies born preterm. Extreme prematurity reduces the risk of atopic dermatitis. Preterm babies showed a peculiar atopic march. |
format | Online Article Text |
id | pubmed-8534898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85348982021-10-23 Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study Pagano, Federica Conti, Maria Giulia Boscarino, Giovanni Pannucci, Chiara Dito, Lucia Regoli, Daniela Di Chiara, Maria Battaglia, Giuseppe Prota, Rita Cinicola, Bianca Zicari, Anna Maria Aloi, Marina Oliva, Salvatore Terrin, Gianluca Children (Basel) Article (1) Background: Preterm birth exposes the infant to the known risk factors for atopic diseases. We aimed to study the neonatal risk factors and to describe the clinical manifestations of atopy, including the march of symptoms, in a cohort of preschool children born preterm. (2) Methods: We enrolled neonates with gestational age < 32 weeks or birth weight < 1500 g. We classified patients in cases and controls according to the presence of at least one atopic manifestation. (3) Results: We observed 72 cases and 93 controls. Multivariate models showed that the administration of more than one cycle of antibiotics (B 0.902, p = 0.026) and gestational diabetes (B 1.207, p = 0.035) influence the risk of atopy in babies born preterm. In addition, risk of atopic dermatitis was influenced by gestational age < 29 weeks (B −1.710, p = 0.025) and gestational diabetes (B 1.275, p = 0.027). The risk of wheeze was associated with familiarity for asthma (B 1.392, p = 0.022) and the administration of more than one cycle of antibiotics (B 0.969, p = 0.025). We observed a significant reduction in the rate of atopic manifestation after 2 years of life (33.9% vs. 23.8%, p < 0.05). (4) Conclusions: Modifiable (gestational diabetes, antibiotics use) and unmodifiable (familiarity for asthma) conditions influence the risk of atopy in babies born preterm. Extreme prematurity reduces the risk of atopic dermatitis. Preterm babies showed a peculiar atopic march. MDPI 2021-09-24 /pmc/articles/PMC8534898/ /pubmed/34682108 http://dx.doi.org/10.3390/children8100843 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pagano, Federica Conti, Maria Giulia Boscarino, Giovanni Pannucci, Chiara Dito, Lucia Regoli, Daniela Di Chiara, Maria Battaglia, Giuseppe Prota, Rita Cinicola, Bianca Zicari, Anna Maria Aloi, Marina Oliva, Salvatore Terrin, Gianluca Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title | Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title_full | Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title_fullStr | Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title_full_unstemmed | Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title_short | Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study |
title_sort | atopic manifestations in children born preterm: a long-term observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534898/ https://www.ncbi.nlm.nih.gov/pubmed/34682108 http://dx.doi.org/10.3390/children8100843 |
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