Cargando…

Unexpected Implication of SRP and AGO2 in Parkinson’s Disease: Involvement in Alpha-Synuclein Biogenesis

Parkinson’s disease (PD) is a neurodegenerative disorder classified by the loss of dopaminergic neurons in the substantia nigra pars compacta, the region of the brain that is responsible for motor control. Surviving neurons in this region contain aggregated protein alpha-Synuclein (αSyn) in the form...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernandez, Sarah M., Tikhonova, Elena B., Baca, Kristen R., Zhao, Fanpeng, Zhu, Xiongwei, Karamyshev, Andrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534902/ https://www.ncbi.nlm.nih.gov/pubmed/34685771 http://dx.doi.org/10.3390/cells10102792

Ejemplares similares

Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson’s Disease
por: Hernandez, Sarah M., et al.
Publicado: (2020)

Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability
por: Pinarbasi, Emile S., et al.
Publicado: (2018)

Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export
por: Grosshans, Helge, et al.
Publicado: (2001)

Unexpected Role of Sterol Synthesis in RNA Stability and Translation in Leishmania
por: Karamysheva, Zemfira N., et al.
Publicado: (2021)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Alpha-synuclein spreading in Parkinson’s disease
por: Recasens, Ariadna, et al.
Publicado: (2014)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
por: Li, Yuanyuan, et al.
Publicado: (2019)

Advances in understanding the function of alpha-synuclein: implications for Parkinson’s disease
por: Calabresi, Paolo, et al.
Publicado: (2023)

Isolating SRP
por: Leslie, Mitch
Publicado: (2005)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
por: Gómez-Benito, Mónica, et al.
Publicado: (2020)

Alpha-Synuclein and Cognitive Decline in Parkinson Disease
por: Fan, Tian-Sin, et al.
Publicado: (2021)

The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease
por: Benskey, Matthew J., et al.
Publicado: (2016)

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
por: Booms, Alix, et al.
Publicado: (2021)

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease
por: Maraganore, Demetrius M.
Publicado: (2011)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
por: Xu, Shengli, et al.
Publicado: (2015)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
por: Zhang, Guoxin, et al.
Publicado: (2018)

The Identification of Alpha-Synuclein as the First Parkinson Disease Gene
por: Nussbaum, Robert L.
Publicado: (2017)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
por: Fitzgerald, Emily, et al.
Publicado: (2019)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
por: Fields, Carroll Rutherford, et al.
Publicado: (2019)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

Myristoylation versus SRP
por: LeBrasseur, Nicole
Publicado: (2005)

Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization
por: Ariesandi, Winny, et al.
Publicado: (2013)

Olfactory Deficits in an Alpha-Synuclein Fly Model of Parkinson’s Disease
por: Chen, Alex Y., et al.
Publicado: (2014)

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease
por: Cersosimo, Maria Graciela
Publicado: (2015)

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease
por: Vivacqua, Giorgio, et al.
Publicado: (2016)

Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
por: Ferreira, Sara A., et al.
Publicado: (2018)

Alpha-synuclein, Proteotoxicity and Parkinson's Disease: Search for Neuroprotective Therapy
por: Ganguly, Upasana, et al.
Publicado: (2018)

Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
por: Limanaqi, Fiona, et al.
Publicado: (2019)

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
por: Meade, Richard M., et al.
Publicado: (2019)

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease
por: White, Alice J., et al.
Publicado: (2018)

Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
por: Teixeira, Maxime, et al.
Publicado: (2021)

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies
por: Menon, Sindhu, et al.
Publicado: (2022)

Diagnostic and therapeutic agents that target alpha-synuclein in Parkinson’s disease
por: Nwabufo, Chukwunonso K., et al.
Publicado: (2022)

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies
por: Bargar, Connor, et al.
Publicado: (2021)

Granulin in Frontotemporal Lobar Degeneration: Molecular Mechanisms of the Disease
por: Karamysheva, Zemfira N., et al.
Publicado: (2019)

Translational Control of Secretory Proteins in Health and Disease
por: Karamyshev, Andrey L., et al.
Publicado: (2020)

Signal Recognition Particle in Human Diseases
por: Kellogg, Morgana K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2m31kl2lr465ssf47tpk5as1j6