Cargando…

Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis

Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are one of the several families of cellular effectors of the prototypical second messenger cAMP. To understand the origin and molecular evolution of EPAC proteins, we performed a comprehensive phylogenetic analysis of EPAC1 and EPAC2. Ou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ni, Zhuofu, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534922/ https://www.ncbi.nlm.nih.gov/pubmed/34685730 http://dx.doi.org/10.3390/cells10102750

Ejemplares similares

A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP
por: Zhu, Yingmin, et al.
Publicado: (2017)

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets
por: Wang, Pingyuan, et al.
Publicado: (2017)

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics
por: Banerjee, Upasana, et al.
Publicado: (2015)

Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP
por: White, Mark A., et al.
Publicado: (2012)

The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
por: McKean, Jenny S., et al.
Publicado: (2015)

Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology
por: White, Mark Andrew, et al.
Publicado: (2019)

Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
por: Søberg, Kristoffer, et al.
Publicado: (2017)

cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis
por: Gárate, Fernanda, et al.
Publicado: (2021)

Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells
por: Drelich, Aleksandra, et al.
Publicado: (2018)

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development
por: Boulton, Stephen, et al.
Publicado: (2023)

Direct regulation of the natural competence regulator gene tfoX by cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Vibrios
por: Wu, Rui, et al.
Publicado: (2015)

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei
por: Bachmaier, Sabine, et al.
Publicado: (2023)

Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice
por: Chen, Yi-fei, et al.
Publicado: (2019)

Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice
por: Aesoy, Reidun, et al.
Publicado: (2018)

Exchange protein directly activated by cAMP 2 is required for corticotropin‐releasing hormone‐mediated spine loss
por: Xie, Zhong, et al.
Publicado: (2019)

Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections
por: Choi, Eun-Jin, et al.
Publicado: (2021)

Exchange Protein Directly Activated by cAMP 2 Enhances Respiratory Syncytial Virus-Induced Pulmonary Disease in Mice
por: Ren, Junping, et al.
Publicado: (2021)

Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression
por: Glas, Evi, et al.
Publicado: (2016)

Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells
por: Jia, Bingbing, et al.
Publicado: (2012)

Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
por: Sivertsen Åsrud, Kathrine, et al.
Publicado: (2019)

Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway
por: Sato, Yukuto, et al.
Publicado: (2009)

Suppression of Virulence of Toxigenic Vibrio cholerae by Anethole through the Cyclic AMP (cAMP)-cAMP Receptor Protein Signaling System
por: Zahid, M. Shamim Hasan, et al.
Publicado: (2015)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Development of green fluorescent protein-based cAMP indicators for covering a wide range of cAMP concentrations
por: Hiasa, Sohei, et al.
Publicado: (2023)

Counterregulation of cAMP-directed kinase activities controls ciliogenesis
por: Porpora, Monia, et al.
Publicado: (2018)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

Activation of cGMP-dependent protein kinase Iα and cAMP-dependent protein kinase A isoforms by cyclic nucleotides
por: Wolter, Sabine, et al.
Publicado: (2011)

Glutaraldehyde fixation of the cAMP-dependent Na+/H+ exchanger in trout red cells
Publicado: (1989)

Epac: new emerging cAMP-binding protein
por: Lee, Kyungmin
Publicado: (2021)

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor
por: Campolo, Federica, et al.
Publicado: (2022)

Regulation of cardiac function by cAMP nanodomains
por: Folkmanaite, Milda, et al.
Publicado: (2023)

Calcium and cAMP directly modulate the speed of the Drosophila circadian clock
por: Palacios-Muñoz, Angelina, et al.
Publicado: (2018)

cAMP Bursts Control T Cell Directionality by Actomyosin Cytoskeleton Remodeling
por: Simao, Morgane, et al.
Publicado: (2021)

Imaging cAMP nanodomains in the heart
por: Chao, Ying-Chi, et al.
Publicado: (2019)

Cyclic 3', 5'-AMP relay in dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP
por: Dinauer, M, et al.
Publicado: (1980)

Cyclic 3', 5'-AMP relay dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation
por: Dinauer, M, et al.
Publicado: (1980)

An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening
por: Liu, Wenfeng, et al.
Publicado: (2022)

A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1
por: Li, Kai, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_poblu1jrb7ii95ee19ic4glk12