The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aim...

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Autores principales: Pileri, Alessandro, Guglielmo, Alba, Grandi, Vieri, Violetti, Silvia Alberti, Fanoni, Daniele, Fava, Paolo, Agostinelli, Claudio, Berti, Emilio, Quaglino, Pietro, Pimpinelli, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534987/
https://www.ncbi.nlm.nih.gov/pubmed/34685762
http://dx.doi.org/10.3390/cells10102780
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author Pileri, Alessandro
Guglielmo, Alba
Grandi, Vieri
Violetti, Silvia Alberti
Fanoni, Daniele
Fava, Paolo
Agostinelli, Claudio
Berti, Emilio
Quaglino, Pietro
Pimpinelli, Nicola
author_facet Pileri, Alessandro
Guglielmo, Alba
Grandi, Vieri
Violetti, Silvia Alberti
Fanoni, Daniele
Fava, Paolo
Agostinelli, Claudio
Berti, Emilio
Quaglino, Pietro
Pimpinelli, Nicola
author_sort Pileri, Alessandro
collection PubMed
description Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
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spelling pubmed-85349872021-10-23 The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications Pileri, Alessandro Guglielmo, Alba Grandi, Vieri Violetti, Silvia Alberti Fanoni, Daniele Fava, Paolo Agostinelli, Claudio Berti, Emilio Quaglino, Pietro Pimpinelli, Nicola Cells Review Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues. MDPI 2021-10-17 /pmc/articles/PMC8534987/ /pubmed/34685762 http://dx.doi.org/10.3390/cells10102780 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pileri, Alessandro
Guglielmo, Alba
Grandi, Vieri
Violetti, Silvia Alberti
Fanoni, Daniele
Fava, Paolo
Agostinelli, Claudio
Berti, Emilio
Quaglino, Pietro
Pimpinelli, Nicola
The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title_full The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title_fullStr The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title_full_unstemmed The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title_short The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
title_sort microenvironment’s role in mycosis fungoides and sézary syndrome: from progression to therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534987/
https://www.ncbi.nlm.nih.gov/pubmed/34685762
http://dx.doi.org/10.3390/cells10102780
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