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Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study

Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and h...

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Autores principales: Shimizu, Shoichi, Ayusawa, Mamoru, Go, Hidetoshi, Nakazaki, Kimitaka, Namiki, Hidemasa, Kasuga, Yuki, Nishimura, Koji, Kanezawa, Koji, Morohashi, Tamaki, Morioka, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535006/
https://www.ncbi.nlm.nih.gov/pubmed/34682178
http://dx.doi.org/10.3390/children8100913
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author Shimizu, Shoichi
Ayusawa, Mamoru
Go, Hidetoshi
Nakazaki, Kimitaka
Namiki, Hidemasa
Kasuga, Yuki
Nishimura, Koji
Kanezawa, Koji
Morohashi, Tamaki
Morioka, Ichiro
author_facet Shimizu, Shoichi
Ayusawa, Mamoru
Go, Hidetoshi
Nakazaki, Kimitaka
Namiki, Hidemasa
Kasuga, Yuki
Nishimura, Koji
Kanezawa, Koji
Morohashi, Tamaki
Morioka, Ichiro
author_sort Shimizu, Shoichi
collection PubMed
description Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases. Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center. Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively. Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our ‘classic’ KD at the present stage.
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spelling pubmed-85350062021-10-23 Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study Shimizu, Shoichi Ayusawa, Mamoru Go, Hidetoshi Nakazaki, Kimitaka Namiki, Hidemasa Kasuga, Yuki Nishimura, Koji Kanezawa, Koji Morohashi, Tamaki Morioka, Ichiro Children (Basel) Article Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases. Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center. Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively. Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our ‘classic’ KD at the present stage. MDPI 2021-10-13 /pmc/articles/PMC8535006/ /pubmed/34682178 http://dx.doi.org/10.3390/children8100913 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimizu, Shoichi
Ayusawa, Mamoru
Go, Hidetoshi
Nakazaki, Kimitaka
Namiki, Hidemasa
Kasuga, Yuki
Nishimura, Koji
Kanezawa, Koji
Morohashi, Tamaki
Morioka, Ichiro
Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title_full Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title_fullStr Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title_full_unstemmed Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title_short Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
title_sort characteristics of kawasaki disease patients during the covid-19 pandemic in japan: a single-center, observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535006/
https://www.ncbi.nlm.nih.gov/pubmed/34682178
http://dx.doi.org/10.3390/children8100913
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