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Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially va...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535022/ https://www.ncbi.nlm.nih.gov/pubmed/34677245 http://dx.doi.org/10.3390/curroncol28050327 |
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author | Saleh, Tareq El-Sadoni, Mohammed Alhesa, Ahmad Awad, Heyam Jaradat, Mahmoud Al-Hazaimeh, Mohammad Dawoud, Rand Mryyian, Amel Azab, Bilal |
author_facet | Saleh, Tareq El-Sadoni, Mohammed Alhesa, Ahmad Awad, Heyam Jaradat, Mahmoud Al-Hazaimeh, Mohammad Dawoud, Rand Mryyian, Amel Azab, Bilal |
author_sort | Saleh, Tareq |
collection | PubMed |
description | Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival. |
format | Online Article Text |
id | pubmed-8535022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85350222021-10-23 Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report Saleh, Tareq El-Sadoni, Mohammed Alhesa, Ahmad Awad, Heyam Jaradat, Mahmoud Al-Hazaimeh, Mohammad Dawoud, Rand Mryyian, Amel Azab, Bilal Curr Oncol Case Report Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival. MDPI 2021-09-30 /pmc/articles/PMC8535022/ /pubmed/34677245 http://dx.doi.org/10.3390/curroncol28050327 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Saleh, Tareq El-Sadoni, Mohammed Alhesa, Ahmad Awad, Heyam Jaradat, Mahmoud Al-Hazaimeh, Mohammad Dawoud, Rand Mryyian, Amel Azab, Bilal Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title_full | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title_fullStr | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title_full_unstemmed | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title_short | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
title_sort | expression of senescence and apoptosis biomarkers in synchronous bilateral breast cancer: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535022/ https://www.ncbi.nlm.nih.gov/pubmed/34677245 http://dx.doi.org/10.3390/curroncol28050327 |
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