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Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report

Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially va...

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Autores principales: Saleh, Tareq, El-Sadoni, Mohammed, Alhesa, Ahmad, Awad, Heyam, Jaradat, Mahmoud, Al-Hazaimeh, Mohammad, Dawoud, Rand, Mryyian, Amel, Azab, Bilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535022/
https://www.ncbi.nlm.nih.gov/pubmed/34677245
http://dx.doi.org/10.3390/curroncol28050327
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author Saleh, Tareq
El-Sadoni, Mohammed
Alhesa, Ahmad
Awad, Heyam
Jaradat, Mahmoud
Al-Hazaimeh, Mohammad
Dawoud, Rand
Mryyian, Amel
Azab, Bilal
author_facet Saleh, Tareq
El-Sadoni, Mohammed
Alhesa, Ahmad
Awad, Heyam
Jaradat, Mahmoud
Al-Hazaimeh, Mohammad
Dawoud, Rand
Mryyian, Amel
Azab, Bilal
author_sort Saleh, Tareq
collection PubMed
description Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.
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spelling pubmed-85350222021-10-23 Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report Saleh, Tareq El-Sadoni, Mohammed Alhesa, Ahmad Awad, Heyam Jaradat, Mahmoud Al-Hazaimeh, Mohammad Dawoud, Rand Mryyian, Amel Azab, Bilal Curr Oncol Case Report Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival. MDPI 2021-09-30 /pmc/articles/PMC8535022/ /pubmed/34677245 http://dx.doi.org/10.3390/curroncol28050327 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Saleh, Tareq
El-Sadoni, Mohammed
Alhesa, Ahmad
Awad, Heyam
Jaradat, Mahmoud
Al-Hazaimeh, Mohammad
Dawoud, Rand
Mryyian, Amel
Azab, Bilal
Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title_full Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title_fullStr Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title_full_unstemmed Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title_short Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
title_sort expression of senescence and apoptosis biomarkers in synchronous bilateral breast cancer: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535022/
https://www.ncbi.nlm.nih.gov/pubmed/34677245
http://dx.doi.org/10.3390/curroncol28050327
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