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Redox Control of the Dormant Cancer Cell Life Cycle

Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances in...

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Detalles Bibliográficos
Autores principales: Li, Bowen, Huang, Yichun, Ming, Hui, Nice, Edouard C., Xuan, Rongrong, Huang, Canhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535080/
https://www.ncbi.nlm.nih.gov/pubmed/34685686
http://dx.doi.org/10.3390/cells10102707
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author Li, Bowen
Huang, Yichun
Ming, Hui
Nice, Edouard C.
Xuan, Rongrong
Huang, Canhua
author_facet Li, Bowen
Huang, Yichun
Ming, Hui
Nice, Edouard C.
Xuan, Rongrong
Huang, Canhua
author_sort Li, Bowen
collection PubMed
description Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances indicate that redox mechanisms control the dormant cancer cell life cycle, including dormancy entrance, long-term dormancy, and metastatic relapse. This regulatory network is orchestrated mainly through redox modification on key regulators or global change of reactive oxygen species (ROS) levels in dormant cancer cells. Encouragingly, several strategies targeting redox signaling, including sleeping, awaking, or killing dormant cancer cells are currently under early clinical evaluation. However, the molecular mechanisms underlying redox control of the dormant cancer cell cycle are poorly understood and need further exploration. In this review, we discuss the underlying molecular basis of redox signaling in the cell life cycle of dormant cancer and the potential redox-based targeting strategies for eliminating dormant cancer cells.
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spelling pubmed-85350802021-10-23 Redox Control of the Dormant Cancer Cell Life Cycle Li, Bowen Huang, Yichun Ming, Hui Nice, Edouard C. Xuan, Rongrong Huang, Canhua Cells Review Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances indicate that redox mechanisms control the dormant cancer cell life cycle, including dormancy entrance, long-term dormancy, and metastatic relapse. This regulatory network is orchestrated mainly through redox modification on key regulators or global change of reactive oxygen species (ROS) levels in dormant cancer cells. Encouragingly, several strategies targeting redox signaling, including sleeping, awaking, or killing dormant cancer cells are currently under early clinical evaluation. However, the molecular mechanisms underlying redox control of the dormant cancer cell cycle are poorly understood and need further exploration. In this review, we discuss the underlying molecular basis of redox signaling in the cell life cycle of dormant cancer and the potential redox-based targeting strategies for eliminating dormant cancer cells. MDPI 2021-10-09 /pmc/articles/PMC8535080/ /pubmed/34685686 http://dx.doi.org/10.3390/cells10102707 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Bowen
Huang, Yichun
Ming, Hui
Nice, Edouard C.
Xuan, Rongrong
Huang, Canhua
Redox Control of the Dormant Cancer Cell Life Cycle
title Redox Control of the Dormant Cancer Cell Life Cycle
title_full Redox Control of the Dormant Cancer Cell Life Cycle
title_fullStr Redox Control of the Dormant Cancer Cell Life Cycle
title_full_unstemmed Redox Control of the Dormant Cancer Cell Life Cycle
title_short Redox Control of the Dormant Cancer Cell Life Cycle
title_sort redox control of the dormant cancer cell life cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535080/
https://www.ncbi.nlm.nih.gov/pubmed/34685686
http://dx.doi.org/10.3390/cells10102707
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