Cargando…
The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder
It has recently been shown that children with early shigellosis are at increased risk of attention deficit/hyperactivity disorder (ADHD). This study aimed to evaluate the association between antibiotic treatment of shigellosis with long-term ADHD rates. A retrospective cohort study was conducted tha...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535120/ https://www.ncbi.nlm.nih.gov/pubmed/34682145 http://dx.doi.org/10.3390/children8100880 |
_version_ | 1784587701921513472 |
---|---|
author | Sadaka, Yair Freedman, Judah Ashkenazi, Shai Vinker, Shlomo Golan-Cohen, Avivit Green, Ilan Israel, Ariel Eran, Alal Merzon, Eugene |
author_facet | Sadaka, Yair Freedman, Judah Ashkenazi, Shai Vinker, Shlomo Golan-Cohen, Avivit Green, Ilan Israel, Ariel Eran, Alal Merzon, Eugene |
author_sort | Sadaka, Yair |
collection | PubMed |
description | It has recently been shown that children with early shigellosis are at increased risk of attention deficit/hyperactivity disorder (ADHD). This study aimed to evaluate the association between antibiotic treatment of shigellosis with long-term ADHD rates. A retrospective cohort study was conducted that included all the Leumit Health Services (LHS) enrollees aged 5–18 years between 2000–2018 with a documented Shigella-positive gastroenteritis before the age of 3 years. Of the 5176 children who were positive for Shigella gastroenteritis before the age of 3 years, 972 (18.8%) were treated with antibiotics early (<5 days), 250 (4.8%) were treated late (≥5 days), and 3954 children (76.4%) were not prescribed antibiotics. Late antibiotic treatment was associated with significantly increased rates of ADHD (adjusted OR = 1.61; 95% CI, 1.1–2.3). Early treatment with antibiotics was not associated with increased ADHD rates (adjusted OR = 1.02; 95% CI, 0.8–1.3). In conclusion, late antibiotic treatment of early childhood shigellosis was associated with increased rates of ADHD. |
format | Online Article Text |
id | pubmed-8535120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85351202021-10-23 The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder Sadaka, Yair Freedman, Judah Ashkenazi, Shai Vinker, Shlomo Golan-Cohen, Avivit Green, Ilan Israel, Ariel Eran, Alal Merzon, Eugene Children (Basel) Article It has recently been shown that children with early shigellosis are at increased risk of attention deficit/hyperactivity disorder (ADHD). This study aimed to evaluate the association between antibiotic treatment of shigellosis with long-term ADHD rates. A retrospective cohort study was conducted that included all the Leumit Health Services (LHS) enrollees aged 5–18 years between 2000–2018 with a documented Shigella-positive gastroenteritis before the age of 3 years. Of the 5176 children who were positive for Shigella gastroenteritis before the age of 3 years, 972 (18.8%) were treated with antibiotics early (<5 days), 250 (4.8%) were treated late (≥5 days), and 3954 children (76.4%) were not prescribed antibiotics. Late antibiotic treatment was associated with significantly increased rates of ADHD (adjusted OR = 1.61; 95% CI, 1.1–2.3). Early treatment with antibiotics was not associated with increased ADHD rates (adjusted OR = 1.02; 95% CI, 0.8–1.3). In conclusion, late antibiotic treatment of early childhood shigellosis was associated with increased rates of ADHD. MDPI 2021-10-02 /pmc/articles/PMC8535120/ /pubmed/34682145 http://dx.doi.org/10.3390/children8100880 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sadaka, Yair Freedman, Judah Ashkenazi, Shai Vinker, Shlomo Golan-Cohen, Avivit Green, Ilan Israel, Ariel Eran, Alal Merzon, Eugene The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title | The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title_full | The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title_fullStr | The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title_full_unstemmed | The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title_short | The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder |
title_sort | effect of antibiotic treatment of early childhood shigellosis on long-term prevalence of attention deficit/hyperactivity disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535120/ https://www.ncbi.nlm.nih.gov/pubmed/34682145 http://dx.doi.org/10.3390/children8100880 |
work_keys_str_mv | AT sadakayair theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT freedmanjudah theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT ashkenazishai theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT vinkershlomo theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT golancohenavivit theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT greenilan theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT israelariel theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT eranalal theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT merzoneugene theeffectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT sadakayair effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT freedmanjudah effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT ashkenazishai effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT vinkershlomo effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT golancohenavivit effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT greenilan effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT israelariel effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT eranalal effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder AT merzoneugene effectofantibiotictreatmentofearlychildhoodshigellosisonlongtermprevalenceofattentiondeficithyperactivitydisorder |