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Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation
Chemotherapy-induced ovarian damage and fertility preservation in young patients with cancer are emerging disciplines. The mechanism of treatment-related gonadal damage provides important information for targeting prevention methods. The genomic aspects of ovarian damage after chemotherapy are not f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535252/ https://www.ncbi.nlm.nih.gov/pubmed/34680919 http://dx.doi.org/10.3390/genes12101525 |
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author | Kim, Seongmin Lee, Sanghoon Park, Hyun-Tae Song, Jae-Yun Kim, Tak |
author_facet | Kim, Seongmin Lee, Sanghoon Park, Hyun-Tae Song, Jae-Yun Kim, Tak |
author_sort | Kim, Seongmin |
collection | PubMed |
description | Chemotherapy-induced ovarian damage and fertility preservation in young patients with cancer are emerging disciplines. The mechanism of treatment-related gonadal damage provides important information for targeting prevention methods. The genomic aspects of ovarian damage after chemotherapy are not fully understood. Several studies have demonstrated that gene alterations related to follicular apoptosis or accelerated follicle activation are related to ovarian insufficiency and susceptibility to ovarian damage following chemotherapy. This may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions after chemotherapy. This review highlights the importance of genomic considerations in chemotherapy-induced ovarian damage and multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients. |
format | Online Article Text |
id | pubmed-8535252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85352522021-10-23 Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation Kim, Seongmin Lee, Sanghoon Park, Hyun-Tae Song, Jae-Yun Kim, Tak Genes (Basel) Review Chemotherapy-induced ovarian damage and fertility preservation in young patients with cancer are emerging disciplines. The mechanism of treatment-related gonadal damage provides important information for targeting prevention methods. The genomic aspects of ovarian damage after chemotherapy are not fully understood. Several studies have demonstrated that gene alterations related to follicular apoptosis or accelerated follicle activation are related to ovarian insufficiency and susceptibility to ovarian damage following chemotherapy. This may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions after chemotherapy. This review highlights the importance of genomic considerations in chemotherapy-induced ovarian damage and multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients. MDPI 2021-09-28 /pmc/articles/PMC8535252/ /pubmed/34680919 http://dx.doi.org/10.3390/genes12101525 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Seongmin Lee, Sanghoon Park, Hyun-Tae Song, Jae-Yun Kim, Tak Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title | Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title_full | Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title_fullStr | Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title_full_unstemmed | Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title_short | Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation |
title_sort | genomic consideration in chemotherapy-induced ovarian damage and fertility preservation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535252/ https://www.ncbi.nlm.nih.gov/pubmed/34680919 http://dx.doi.org/10.3390/genes12101525 |
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