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Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome
Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535327/ https://www.ncbi.nlm.nih.gov/pubmed/34682436 http://dx.doi.org/10.3390/ijerph182010689 |
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author | Mariani, Jacopo Iodice, Simona Cantone, Laura Solazzo, Giulia Marraccini, Paolo Conforti, Emanuele Bulsara, Pallav A. Lombardi, Maria Stella Howlin, Robert P. Bollati, Valentina Ferrari, Luca |
author_facet | Mariani, Jacopo Iodice, Simona Cantone, Laura Solazzo, Giulia Marraccini, Paolo Conforti, Emanuele Bulsara, Pallav A. Lombardi, Maria Stella Howlin, Robert P. Bollati, Valentina Ferrari, Luca |
author_sort | Mariani, Jacopo |
collection | PubMed |
description | Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM(10) and PM(2.5) exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse. |
format | Online Article Text |
id | pubmed-8535327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85353272021-10-23 Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome Mariani, Jacopo Iodice, Simona Cantone, Laura Solazzo, Giulia Marraccini, Paolo Conforti, Emanuele Bulsara, Pallav A. Lombardi, Maria Stella Howlin, Robert P. Bollati, Valentina Ferrari, Luca Int J Environ Res Public Health Article Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM(10) and PM(2.5) exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse. MDPI 2021-10-12 /pmc/articles/PMC8535327/ /pubmed/34682436 http://dx.doi.org/10.3390/ijerph182010689 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mariani, Jacopo Iodice, Simona Cantone, Laura Solazzo, Giulia Marraccini, Paolo Conforti, Emanuele Bulsara, Pallav A. Lombardi, Maria Stella Howlin, Robert P. Bollati, Valentina Ferrari, Luca Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title | Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title_full | Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title_fullStr | Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title_full_unstemmed | Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title_short | Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome |
title_sort | particulate matter exposure and allergic rhinitis: the role of plasmatic extracellular vesicles and bacterial nasal microbiome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535327/ https://www.ncbi.nlm.nih.gov/pubmed/34682436 http://dx.doi.org/10.3390/ijerph182010689 |
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