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Association of PIP4K2A Polymorphisms with Alcohol Use Disorder
Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 α (PIP4K2A) pla...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535504/ https://www.ncbi.nlm.nih.gov/pubmed/34681036 http://dx.doi.org/10.3390/genes12101642 |
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author | Fedorenko, Olga Yu. Mikhalitskaya, Ekaterina V. Toshchakova, Valentina A. Loonen, Anton J. M. Bokhan, Nikolay A. Ivanova, Svetlana A. |
author_facet | Fedorenko, Olga Yu. Mikhalitskaya, Ekaterina V. Toshchakova, Valentina A. Loonen, Anton J. M. Bokhan, Nikolay A. Ivanova, Svetlana A. |
author_sort | Fedorenko, Olga Yu. |
collection | PubMed |
description | Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 α (PIP4K2A) plays an important role in the regulation of ascending dopamine pathways. In this study; we determined possible associations between nine polymorphisms in PIP4K2A and AUD in Russian men. Methods: 279 Russian men with AUD were investigated. The control group consisted of 222 healthy men from the general Russian population. Genotyping of DNA samples for nine polymorphic variants of PIP4K2A was carried out by the Applied Biosystems™ QuantStudio™ 5 Real-Time PCR System with use of the TaqMan1 Validated SNP Genotyping Assay (Applied Biosystems; CIIIA). Results: Carriage of the PIP4K2A rs2230469*TT/T genotype/allele was a relative risk factor for developing AUD in men (p = 0.026 and p = 0.0084 accordingly). Moreover; men with AUD had a higher frequency of PIP4K2A rs746203*T allele (p = 0.023) compared to healthy men. Conclusions: For the first time; we demonstrated different PIP4K2A polymorphisms to be associated with AUD presumably due to dopamine system modulation resulting from regulation of the lateral habenula. |
format | Online Article Text |
id | pubmed-8535504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85355042021-10-23 Association of PIP4K2A Polymorphisms with Alcohol Use Disorder Fedorenko, Olga Yu. Mikhalitskaya, Ekaterina V. Toshchakova, Valentina A. Loonen, Anton J. M. Bokhan, Nikolay A. Ivanova, Svetlana A. Genes (Basel) Article Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 α (PIP4K2A) plays an important role in the regulation of ascending dopamine pathways. In this study; we determined possible associations between nine polymorphisms in PIP4K2A and AUD in Russian men. Methods: 279 Russian men with AUD were investigated. The control group consisted of 222 healthy men from the general Russian population. Genotyping of DNA samples for nine polymorphic variants of PIP4K2A was carried out by the Applied Biosystems™ QuantStudio™ 5 Real-Time PCR System with use of the TaqMan1 Validated SNP Genotyping Assay (Applied Biosystems; CIIIA). Results: Carriage of the PIP4K2A rs2230469*TT/T genotype/allele was a relative risk factor for developing AUD in men (p = 0.026 and p = 0.0084 accordingly). Moreover; men with AUD had a higher frequency of PIP4K2A rs746203*T allele (p = 0.023) compared to healthy men. Conclusions: For the first time; we demonstrated different PIP4K2A polymorphisms to be associated with AUD presumably due to dopamine system modulation resulting from regulation of the lateral habenula. MDPI 2021-10-19 /pmc/articles/PMC8535504/ /pubmed/34681036 http://dx.doi.org/10.3390/genes12101642 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fedorenko, Olga Yu. Mikhalitskaya, Ekaterina V. Toshchakova, Valentina A. Loonen, Anton J. M. Bokhan, Nikolay A. Ivanova, Svetlana A. Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title_full | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title_fullStr | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title_full_unstemmed | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title_short | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |
title_sort | association of pip4k2a polymorphisms with alcohol use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535504/ https://www.ncbi.nlm.nih.gov/pubmed/34681036 http://dx.doi.org/10.3390/genes12101642 |
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