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Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf1...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535512/ https://www.ncbi.nlm.nih.gov/pubmed/34682384 http://dx.doi.org/10.3390/ijerph182010639 |
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author | Carugno, Michele Maggioni, Cristina Ruggiero, Vincenzo Crespi, Eleonora Monti, Paola Ferrari, Luca Pesatori, Angela Cecilia |
author_facet | Carugno, Michele Maggioni, Cristina Ruggiero, Vincenzo Crespi, Eleonora Monti, Paola Ferrari, Luca Pesatori, Angela Cecilia |
author_sort | Carugno, Michele |
collection | PubMed |
description | Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagues not working in NS. Each subject filled in a questionnaire (including the Effort Reward Imbalance (ERI) index to assess job stress) and gave a blood sample. Age acceleration (AA) was estimated by regressing BA on chronological age and taking the residuals. Multivariate linear regression models were applied. BA was not associated with NS. However, we did observe an increase in AA per each year in NS in subjects with overweight/obesity (β = 0.46, 95% CI: 0.05; 0.87, p = 0.03), experiencing work-related stress (β = 0.58, 95% CI: 0.10; 1.06, p = 0.018), or both (β = 0.66, 95% CI: 0.03; 1.29, p = 0.041). Although based on a small sample size, our findings suggest an increased BA only among hypersusceptible subjects and is worth further investigation, also in light of recent results suggesting a higher breast cancer risk in women with increased AA. |
format | Online Article Text |
id | pubmed-8535512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85355122021-10-23 Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses Carugno, Michele Maggioni, Cristina Ruggiero, Vincenzo Crespi, Eleonora Monti, Paola Ferrari, Luca Pesatori, Angela Cecilia Int J Environ Res Public Health Communication Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagues not working in NS. Each subject filled in a questionnaire (including the Effort Reward Imbalance (ERI) index to assess job stress) and gave a blood sample. Age acceleration (AA) was estimated by regressing BA on chronological age and taking the residuals. Multivariate linear regression models were applied. BA was not associated with NS. However, we did observe an increase in AA per each year in NS in subjects with overweight/obesity (β = 0.46, 95% CI: 0.05; 0.87, p = 0.03), experiencing work-related stress (β = 0.58, 95% CI: 0.10; 1.06, p = 0.018), or both (β = 0.66, 95% CI: 0.03; 1.29, p = 0.041). Although based on a small sample size, our findings suggest an increased BA only among hypersusceptible subjects and is worth further investigation, also in light of recent results suggesting a higher breast cancer risk in women with increased AA. MDPI 2021-10-11 /pmc/articles/PMC8535512/ /pubmed/34682384 http://dx.doi.org/10.3390/ijerph182010639 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Carugno, Michele Maggioni, Cristina Ruggiero, Vincenzo Crespi, Eleonora Monti, Paola Ferrari, Luca Pesatori, Angela Cecilia Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title | Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title_full | Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title_fullStr | Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title_full_unstemmed | Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title_short | Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses |
title_sort | can night shift work affect biological age? hints from a cross-sectional study on hospital female nurses |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535512/ https://www.ncbi.nlm.nih.gov/pubmed/34682384 http://dx.doi.org/10.3390/ijerph182010639 |
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