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Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses

Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf1...

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Autores principales: Carugno, Michele, Maggioni, Cristina, Ruggiero, Vincenzo, Crespi, Eleonora, Monti, Paola, Ferrari, Luca, Pesatori, Angela Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535512/
https://www.ncbi.nlm.nih.gov/pubmed/34682384
http://dx.doi.org/10.3390/ijerph182010639
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author Carugno, Michele
Maggioni, Cristina
Ruggiero, Vincenzo
Crespi, Eleonora
Monti, Paola
Ferrari, Luca
Pesatori, Angela Cecilia
author_facet Carugno, Michele
Maggioni, Cristina
Ruggiero, Vincenzo
Crespi, Eleonora
Monti, Paola
Ferrari, Luca
Pesatori, Angela Cecilia
author_sort Carugno, Michele
collection PubMed
description Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagues not working in NS. Each subject filled in a questionnaire (including the Effort Reward Imbalance (ERI) index to assess job stress) and gave a blood sample. Age acceleration (AA) was estimated by regressing BA on chronological age and taking the residuals. Multivariate linear regression models were applied. BA was not associated with NS. However, we did observe an increase in AA per each year in NS in subjects with overweight/obesity (β = 0.46, 95% CI: 0.05; 0.87, p = 0.03), experiencing work-related stress (β = 0.58, 95% CI: 0.10; 1.06, p = 0.018), or both (β = 0.66, 95% CI: 0.03; 1.29, p = 0.041). Although based on a small sample size, our findings suggest an increased BA only among hypersusceptible subjects and is worth further investigation, also in light of recent results suggesting a higher breast cancer risk in women with increased AA.
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spelling pubmed-85355122021-10-23 Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses Carugno, Michele Maggioni, Cristina Ruggiero, Vincenzo Crespi, Eleonora Monti, Paola Ferrari, Luca Pesatori, Angela Cecilia Int J Environ Res Public Health Communication Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagues not working in NS. Each subject filled in a questionnaire (including the Effort Reward Imbalance (ERI) index to assess job stress) and gave a blood sample. Age acceleration (AA) was estimated by regressing BA on chronological age and taking the residuals. Multivariate linear regression models were applied. BA was not associated with NS. However, we did observe an increase in AA per each year in NS in subjects with overweight/obesity (β = 0.46, 95% CI: 0.05; 0.87, p = 0.03), experiencing work-related stress (β = 0.58, 95% CI: 0.10; 1.06, p = 0.018), or both (β = 0.66, 95% CI: 0.03; 1.29, p = 0.041). Although based on a small sample size, our findings suggest an increased BA only among hypersusceptible subjects and is worth further investigation, also in light of recent results suggesting a higher breast cancer risk in women with increased AA. MDPI 2021-10-11 /pmc/articles/PMC8535512/ /pubmed/34682384 http://dx.doi.org/10.3390/ijerph182010639 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Carugno, Michele
Maggioni, Cristina
Ruggiero, Vincenzo
Crespi, Eleonora
Monti, Paola
Ferrari, Luca
Pesatori, Angela Cecilia
Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title_full Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title_fullStr Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title_full_unstemmed Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title_short Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
title_sort can night shift work affect biological age? hints from a cross-sectional study on hospital female nurses
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535512/
https://www.ncbi.nlm.nih.gov/pubmed/34682384
http://dx.doi.org/10.3390/ijerph182010639
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