Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report

We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD...

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Autores principales: Jassem, Jacek, Marek-Trzonkowska, Natalia Maria, Smiatacz, Tomasz, Arcimowicz, Łukasz, Papak, Ines, Jassem, Ewa, Zaucha, Jan Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535727/
https://www.ncbi.nlm.nih.gov/pubmed/34681595
http://dx.doi.org/10.3390/ijms222010934
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author Jassem, Jacek
Marek-Trzonkowska, Natalia Maria
Smiatacz, Tomasz
Arcimowicz, Łukasz
Papak, Ines
Jassem, Ewa
Zaucha, Jan Maciej
author_facet Jassem, Jacek
Marek-Trzonkowska, Natalia Maria
Smiatacz, Tomasz
Arcimowicz, Łukasz
Papak, Ines
Jassem, Ewa
Zaucha, Jan Maciej
author_sort Jassem, Jacek
collection PubMed
description We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectively respond to anti-SARS-CoV-2 treatment when NK and antigen-specific Tc cell response is induced.
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spelling pubmed-85357272021-10-23 Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report Jassem, Jacek Marek-Trzonkowska, Natalia Maria Smiatacz, Tomasz Arcimowicz, Łukasz Papak, Ines Jassem, Ewa Zaucha, Jan Maciej Int J Mol Sci Case Report We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectively respond to anti-SARS-CoV-2 treatment when NK and antigen-specific Tc cell response is induced. MDPI 2021-10-10 /pmc/articles/PMC8535727/ /pubmed/34681595 http://dx.doi.org/10.3390/ijms222010934 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jassem, Jacek
Marek-Trzonkowska, Natalia Maria
Smiatacz, Tomasz
Arcimowicz, Łukasz
Papak, Ines
Jassem, Ewa
Zaucha, Jan Maciej
Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title_full Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title_fullStr Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title_full_unstemmed Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title_short Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
title_sort successful treatment of persistent sars-cov-2 infection in a b-cell depleted patient with activated cytotoxic t and nk cells: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535727/
https://www.ncbi.nlm.nih.gov/pubmed/34681595
http://dx.doi.org/10.3390/ijms222010934
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