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Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA
The processing of DNA double-strand breaks (DSBs) depends on the dynamic characteristics of chromatin. To investigate how abrupt changes in chromatin compaction alter these dynamics and affect DSB processing and repair, we exposed irradiated cells to hypotonic stress (HypoS). Densitometric and chrom...
Autores principales: | Krieger, Lisa Marie, Mladenov, Emil, Soni, Aashish, Demond, Marilen, Stuschke, Martin, Iliakis, George |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535785/ https://www.ncbi.nlm.nih.gov/pubmed/34681628 http://dx.doi.org/10.3390/ijms222010957 |
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