Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss of function of the X-linked methyl-CpG–binding protein 2 (MECP2). Several case studies report that gross motor function can be improved in children with RTT through treadmill walking, but whether the MeCP2-deficient motor cir...

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Detalles Bibliográficos
Autores principales: Yue, Yuanlei, Xu, Pan, Liu, Zhichao, Sun, Xiaoqian, Su, Juntao, Du, Hongfei, Chen, Lingling, Ash, Ryan T., Smirnakis, Stelios, Simha, Rahul, Kusner, Linda, Zeng, Chen, Lu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535852/
https://www.ncbi.nlm.nih.gov/pubmed/34678068
http://dx.doi.org/10.1126/sciadv.abf7467

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