The Role of MSCs and Cell Fusion in Tissue Regeneration

Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due t...

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Detalles Bibliográficos
Autores principales: Dörnen, Jessica, Dittmar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535885/
https://www.ncbi.nlm.nih.gov/pubmed/34681639
http://dx.doi.org/10.3390/ijms222010980
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author Dörnen, Jessica
Dittmar, Thomas
author_facet Dörnen, Jessica
Dittmar, Thomas
author_sort Dörnen, Jessica
collection PubMed
description Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due to their role in tissue regeneration, immunomodulatory capacity and low immunogenicity. So far, clinical studies are not very conclusive as they show conflicting efficacies regarding the use of MSCs. An additional process possibly involved in regeneration might be cell fusion. This process occurs in both a physiological and a pathophysiological context and can be affected by immune response due to inflammation. In this review the role of MSCs and cell fusion in tissue regeneration is discussed.
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spelling pubmed-85358852021-10-23 The Role of MSCs and Cell Fusion in Tissue Regeneration Dörnen, Jessica Dittmar, Thomas Int J Mol Sci Review Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due to their role in tissue regeneration, immunomodulatory capacity and low immunogenicity. So far, clinical studies are not very conclusive as they show conflicting efficacies regarding the use of MSCs. An additional process possibly involved in regeneration might be cell fusion. This process occurs in both a physiological and a pathophysiological context and can be affected by immune response due to inflammation. In this review the role of MSCs and cell fusion in tissue regeneration is discussed. MDPI 2021-10-12 /pmc/articles/PMC8535885/ /pubmed/34681639 http://dx.doi.org/10.3390/ijms222010980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dörnen, Jessica
Dittmar, Thomas
The Role of MSCs and Cell Fusion in Tissue Regeneration
title The Role of MSCs and Cell Fusion in Tissue Regeneration
title_full The Role of MSCs and Cell Fusion in Tissue Regeneration
title_fullStr The Role of MSCs and Cell Fusion in Tissue Regeneration
title_full_unstemmed The Role of MSCs and Cell Fusion in Tissue Regeneration
title_short The Role of MSCs and Cell Fusion in Tissue Regeneration
title_sort role of mscs and cell fusion in tissue regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535885/
https://www.ncbi.nlm.nih.gov/pubmed/34681639
http://dx.doi.org/10.3390/ijms222010980
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