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Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis

Psoriasis is a chronic inflammatory disease which is caused by the interaction between genetic and environmental factors. Evidence shows an association of psoriasis with co-morbidities including cardiovascular diseases, metabolic syndrome and hyperuricemia. Genome-wide association studies have revea...

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Autores principales: Huang, Yu-Huei, See, Lai-Chu, Chang, Ya-Ching, Chung, Wen-Hung, Chang, Lun-Ching, Yang, Shun-Fa, Su, Shih-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535938/
https://www.ncbi.nlm.nih.gov/pubmed/34680995
http://dx.doi.org/10.3390/genes12101601
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author Huang, Yu-Huei
See, Lai-Chu
Chang, Ya-Ching
Chung, Wen-Hung
Chang, Lun-Ching
Yang, Shun-Fa
Su, Shih-Chi
author_facet Huang, Yu-Huei
See, Lai-Chu
Chang, Ya-Ching
Chung, Wen-Hung
Chang, Lun-Ching
Yang, Shun-Fa
Su, Shih-Chi
author_sort Huang, Yu-Huei
collection PubMed
description Psoriasis is a chronic inflammatory disease which is caused by the interaction between genetic and environmental factors. Evidence shows an association of psoriasis with co-morbidities including cardiovascular diseases, metabolic syndrome and hyperuricemia. Genome-wide association studies have revealed that the ABCG2 gene encoding ATP-binding cassette G2 protein was associated with inflammation and higher serum urate concentrations. In this study, we aimed to evaluate the role of ABCG2 gene polymorphisms on the susceptibility to psoriasis. The genotype distribution of two ABCG2 single nucleotide polymorphisms (SNPs), rs2231142 and rs2231137, was examined in 410 psoriasis patients and 1,089 gender-matched non-psoriasis controls. We found that heterozygotes (GT) for rs2231142 was associated with a decreased risk of psoriasis (p = 0.001; adjusted OR = 0.532; 95% CI, 0.370–0.765) after adjusting for age, as compared with homozygotes for the major allele (GG). Subjects who carried at least one polymorphic allele (homozygote or heterozygote for the minor allele) were less susceptible to psoriasis (p = 0.002; adjusted OR = 0.594; 95% CI, 0.249–0.823) and bearing higher serum urate levels (p = 0.026) than those homozygous for the major allele. Our results indicated that the ABCG2 gene polymorphism was associated with the risk of psoriasis.
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spelling pubmed-85359382021-10-23 Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis Huang, Yu-Huei See, Lai-Chu Chang, Ya-Ching Chung, Wen-Hung Chang, Lun-Ching Yang, Shun-Fa Su, Shih-Chi Genes (Basel) Article Psoriasis is a chronic inflammatory disease which is caused by the interaction between genetic and environmental factors. Evidence shows an association of psoriasis with co-morbidities including cardiovascular diseases, metabolic syndrome and hyperuricemia. Genome-wide association studies have revealed that the ABCG2 gene encoding ATP-binding cassette G2 protein was associated with inflammation and higher serum urate concentrations. In this study, we aimed to evaluate the role of ABCG2 gene polymorphisms on the susceptibility to psoriasis. The genotype distribution of two ABCG2 single nucleotide polymorphisms (SNPs), rs2231142 and rs2231137, was examined in 410 psoriasis patients and 1,089 gender-matched non-psoriasis controls. We found that heterozygotes (GT) for rs2231142 was associated with a decreased risk of psoriasis (p = 0.001; adjusted OR = 0.532; 95% CI, 0.370–0.765) after adjusting for age, as compared with homozygotes for the major allele (GG). Subjects who carried at least one polymorphic allele (homozygote or heterozygote for the minor allele) were less susceptible to psoriasis (p = 0.002; adjusted OR = 0.594; 95% CI, 0.249–0.823) and bearing higher serum urate levels (p = 0.026) than those homozygous for the major allele. Our results indicated that the ABCG2 gene polymorphism was associated with the risk of psoriasis. MDPI 2021-10-12 /pmc/articles/PMC8535938/ /pubmed/34680995 http://dx.doi.org/10.3390/genes12101601 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yu-Huei
See, Lai-Chu
Chang, Ya-Ching
Chung, Wen-Hung
Chang, Lun-Ching
Yang, Shun-Fa
Su, Shih-Chi
Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title_full Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title_fullStr Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title_full_unstemmed Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title_short Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis
title_sort impact of abcg2 gene polymorphism on the predisposition to psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535938/
https://www.ncbi.nlm.nih.gov/pubmed/34680995
http://dx.doi.org/10.3390/genes12101601
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