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Expression of Matrix Metalloproteinase-9 in Gastric Cancer
Background Matrix-metalloproteinase-9 (MMP-9) is expressed by a wide range of cells and plays a significant role in the regulation of the tumor microenvironment of various cancers including gastric cancer. This study aims at the correlation of MMP-9 expression in gastric cancer with existing prognos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536001/ https://www.ncbi.nlm.nih.gov/pubmed/34707964 http://dx.doi.org/10.7759/cureus.18195 |
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author | R, Prathipaa N, Priyathersini J, Thanka |
author_facet | R, Prathipaa N, Priyathersini J, Thanka |
author_sort | R, Prathipaa |
collection | PubMed |
description | Background Matrix-metalloproteinase-9 (MMP-9) is expressed by a wide range of cells and plays a significant role in the regulation of the tumor microenvironment of various cancers including gastric cancer. This study aims at the correlation of MMP-9 expression in gastric cancer with existing prognostic factors. Methods The MMP-9 expression in gastric cancer was identified by immunohistochemistry using a monoclonal antibody in paraffin-embedded sections, correlated with various clinicopathological parameters, and statistically analyzed. Results MMP-9 expression in gastric cancer was significantly correlated with the grade, depth of invasion, and TNM stage (p-value = 0.003, 0.019, and 0.025, respectively). A significant difference in expression between tumor tissue and adjacent gastric mucosa (p-value = 0.000) was also observed. 100% negative expression was found in well-differentiated tumors and early gastric carcinoma (T1). Conclusion The study results suggest that MMP-9 expression could be a potential biomarker of aggressive gastric cancer and candidates for the possible diagnostic and prognostic tool. |
format | Online Article Text |
id | pubmed-8536001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-85360012021-10-26 Expression of Matrix Metalloproteinase-9 in Gastric Cancer R, Prathipaa N, Priyathersini J, Thanka Cureus Internal Medicine Background Matrix-metalloproteinase-9 (MMP-9) is expressed by a wide range of cells and plays a significant role in the regulation of the tumor microenvironment of various cancers including gastric cancer. This study aims at the correlation of MMP-9 expression in gastric cancer with existing prognostic factors. Methods The MMP-9 expression in gastric cancer was identified by immunohistochemistry using a monoclonal antibody in paraffin-embedded sections, correlated with various clinicopathological parameters, and statistically analyzed. Results MMP-9 expression in gastric cancer was significantly correlated with the grade, depth of invasion, and TNM stage (p-value = 0.003, 0.019, and 0.025, respectively). A significant difference in expression between tumor tissue and adjacent gastric mucosa (p-value = 0.000) was also observed. 100% negative expression was found in well-differentiated tumors and early gastric carcinoma (T1). Conclusion The study results suggest that MMP-9 expression could be a potential biomarker of aggressive gastric cancer and candidates for the possible diagnostic and prognostic tool. Cureus 2021-09-22 /pmc/articles/PMC8536001/ /pubmed/34707964 http://dx.doi.org/10.7759/cureus.18195 Text en Copyright © 2021, R et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine R, Prathipaa N, Priyathersini J, Thanka Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title | Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title_full | Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title_fullStr | Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title_full_unstemmed | Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title_short | Expression of Matrix Metalloproteinase-9 in Gastric Cancer |
title_sort | expression of matrix metalloproteinase-9 in gastric cancer |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536001/ https://www.ncbi.nlm.nih.gov/pubmed/34707964 http://dx.doi.org/10.7759/cureus.18195 |
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