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CKM Gene rs8111989 Polymorphism and Power Athlete Status
Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536047/ https://www.ncbi.nlm.nih.gov/pubmed/34680894 http://dx.doi.org/10.3390/genes12101499 |
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author | Ginevičienė, Valentina Jakaitienė, Audronė Utkus, Algirdas Hall, Elliott C. R. Semenova, Ekaterina A. Andryushchenko, Liliya B. Larin, Andrey K. Moreland, Ethan Generozov, Edward V. Ahmetov, Ildus I. |
author_facet | Ginevičienė, Valentina Jakaitienė, Audronė Utkus, Algirdas Hall, Elliott C. R. Semenova, Ekaterina A. Andryushchenko, Liliya B. Larin, Andrey K. Moreland, Ethan Generozov, Edward V. Ahmetov, Ildus I. |
author_sort | Ginevičienė, Valentina |
collection | PubMed |
description | Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success. |
format | Online Article Text |
id | pubmed-8536047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85360472021-10-23 CKM Gene rs8111989 Polymorphism and Power Athlete Status Ginevičienė, Valentina Jakaitienė, Audronė Utkus, Algirdas Hall, Elliott C. R. Semenova, Ekaterina A. Andryushchenko, Liliya B. Larin, Andrey K. Moreland, Ethan Generozov, Edward V. Ahmetov, Ildus I. Genes (Basel) Article Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success. MDPI 2021-09-25 /pmc/articles/PMC8536047/ /pubmed/34680894 http://dx.doi.org/10.3390/genes12101499 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ginevičienė, Valentina Jakaitienė, Audronė Utkus, Algirdas Hall, Elliott C. R. Semenova, Ekaterina A. Andryushchenko, Liliya B. Larin, Andrey K. Moreland, Ethan Generozov, Edward V. Ahmetov, Ildus I. CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title | CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title_full | CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title_fullStr | CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title_full_unstemmed | CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title_short | CKM Gene rs8111989 Polymorphism and Power Athlete Status |
title_sort | ckm gene rs8111989 polymorphism and power athlete status |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536047/ https://www.ncbi.nlm.nih.gov/pubmed/34680894 http://dx.doi.org/10.3390/genes12101499 |
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