Novel Synthesized N-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation

A series of novel hybrid chalcone N-ethyl-piperazinyl amide derivatives of oleanonic and ursonic acids were synthesized, and their cytotoxic potential was evaluated in vitro against the NCI-60 cancer cell line panel. Compounds 4 and 6 exhibited the highest overall anticancer activity, with GI(50) va...

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Detalles Bibliográficos
Autores principales: Kazakova, Oxana, Mioc, Alexandra, Smirnova, Irina, Baikova, Irina, Voicu, Adrian, Vlaia, Lavinia, Macașoi, Ioana, Mioc, Marius, Drăghici, George, Avram, Ştefana, Dehelean, Cristina, Şoica, Codruța
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536124/
https://www.ncbi.nlm.nih.gov/pubmed/34681629
http://dx.doi.org/10.3390/ijms222010967

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