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Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

Transcription initiation starts with unwinding of promoter DNA by RNA polymerase (RNAP) to form a catalytically competent RNAP-promoter complex (RPo). Despite extensive study, the mechanism of promoter unwinding has remained unclear, in part due to the transient nature of intermediates on path to RP...

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Detalles Bibliográficos
Autores principales:	Mazumder, Abhishek, Ebright, Richard H, Kapanidis, Achillefs N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536254/ https://www.ncbi.nlm.nih.gov/pubmed/34633286 http://dx.doi.org/10.7554/eLife.70090

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