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Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536258/ https://www.ncbi.nlm.nih.gov/pubmed/34590579 http://dx.doi.org/10.7554/eLife.69749 |
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author | Reilein, Amy Kogan, Helen V Misner, Rachel Park, Karen Sophia Kalderon, Daniel |
author_facet | Reilein, Amy Kogan, Helen V Misner, Rachel Park, Karen Sophia Kalderon, Daniel |
author_sort | Reilein, Amy |
collection | PubMed |
description | Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events. |
format | Online Article Text |
id | pubmed-8536258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85362582021-10-25 Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development Reilein, Amy Kogan, Helen V Misner, Rachel Park, Karen Sophia Kalderon, Daniel eLife Developmental Biology Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events. eLife Sciences Publications, Ltd 2021-09-30 /pmc/articles/PMC8536258/ /pubmed/34590579 http://dx.doi.org/10.7554/eLife.69749 Text en © 2021, Reilein et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Reilein, Amy Kogan, Helen V Misner, Rachel Park, Karen Sophia Kalderon, Daniel Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title | Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title_full | Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title_fullStr | Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title_full_unstemmed | Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title_short | Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development |
title_sort | adult stem cells and niche cells segregate gradually from common precursors that build the adult drosophila ovary during pupal development |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536258/ https://www.ncbi.nlm.nih.gov/pubmed/34590579 http://dx.doi.org/10.7554/eLife.69749 |
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