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Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal p...

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Autores principales: Reilein, Amy, Kogan, Helen V, Misner, Rachel, Park, Karen Sophia, Kalderon, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536258/
https://www.ncbi.nlm.nih.gov/pubmed/34590579
http://dx.doi.org/10.7554/eLife.69749
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author Reilein, Amy
Kogan, Helen V
Misner, Rachel
Park, Karen Sophia
Kalderon, Daniel
author_facet Reilein, Amy
Kogan, Helen V
Misner, Rachel
Park, Karen Sophia
Kalderon, Daniel
author_sort Reilein, Amy
collection PubMed
description Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events.
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spelling pubmed-85362582021-10-25 Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development Reilein, Amy Kogan, Helen V Misner, Rachel Park, Karen Sophia Kalderon, Daniel eLife Developmental Biology Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events. eLife Sciences Publications, Ltd 2021-09-30 /pmc/articles/PMC8536258/ /pubmed/34590579 http://dx.doi.org/10.7554/eLife.69749 Text en © 2021, Reilein et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Reilein, Amy
Kogan, Helen V
Misner, Rachel
Park, Karen Sophia
Kalderon, Daniel
Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_full Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_fullStr Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_full_unstemmed Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_short Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_sort adult stem cells and niche cells segregate gradually from common precursors that build the adult drosophila ovary during pupal development
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536258/
https://www.ncbi.nlm.nih.gov/pubmed/34590579
http://dx.doi.org/10.7554/eLife.69749
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