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The N terminus of α-synuclein dictates fibril formation

The generation of α-synuclein (α-syn) truncations from incomplete proteolysis plays a significant role in the pathogenesis of Parkinson’s disease. It is well established that C-terminal truncations exhibit accelerated aggregation and serve as potent seeds in fibril propagation. In contrast, mechanis...

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Detalles Bibliográficos
Autores principales:	McGlinchey, Ryan P., Ni, Xiaodan, Shadish, Jared A., Jiang, Jiansen, Lee, Jennifer C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536336/ https://www.ncbi.nlm.nih.gov/pubmed/34452994 http://dx.doi.org/10.1073/pnas.2023487118

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