Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans?

New synthetic opioids (NSOs) pose a public health concern since their emergence on the illicit drug market and are gaining increasing importance in forensic toxicology. Like many other new psychoactive substances, NSOs are consumed without any preclinical safety data or any knowledge on toxicokineti...

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Detalles Bibliográficos
Autores principales: Nordmeier, Frederike, Sihinevich, Iryna, Doerr, Adrian A., Walle, Nadja, Laschke, Matthias W., Lehr, Thorsten, Menger, Michael D., Schmidt, Peter H., Meyer, Markus R., Schaefer, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536616/
https://www.ncbi.nlm.nih.gov/pubmed/34604914
http://dx.doi.org/10.1007/s00204-021-03169-y

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