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Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria

Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial...

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Autores principales: Long, Yanping, Li, Ling, Xu, Tao, Wu, Xizheng, Gao, Yun, Huang, Jianbo, He, Chao, Ma, Tian, Ma, Lang, Cheng, Chong, Zhao, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536674/
https://www.ncbi.nlm.nih.gov/pubmed/34686676
http://dx.doi.org/10.1038/s41467-021-26456-9
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author Long, Yanping
Li, Ling
Xu, Tao
Wu, Xizheng
Gao, Yun
Huang, Jianbo
He, Chao
Ma, Tian
Ma, Lang
Cheng, Chong
Zhao, Changsheng
author_facet Long, Yanping
Li, Ling
Xu, Tao
Wu, Xizheng
Gao, Yun
Huang, Jianbo
He, Chao
Ma, Tian
Ma, Lang
Cheng, Chong
Zhao, Changsheng
author_sort Long, Yanping
collection PubMed
description Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O(2)(−) and HClO with its Fe(2)N(6)O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H(2)O(2) (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies.
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spelling pubmed-85366742021-11-15 Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria Long, Yanping Li, Ling Xu, Tao Wu, Xizheng Gao, Yun Huang, Jianbo He, Chao Ma, Tian Ma, Lang Cheng, Chong Zhao, Changsheng Nat Commun Article Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O(2)(−) and HClO with its Fe(2)N(6)O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H(2)O(2) (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies. Nature Publishing Group UK 2021-10-22 /pmc/articles/PMC8536674/ /pubmed/34686676 http://dx.doi.org/10.1038/s41467-021-26456-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Long, Yanping
Li, Ling
Xu, Tao
Wu, Xizheng
Gao, Yun
Huang, Jianbo
He, Chao
Ma, Tian
Ma, Lang
Cheng, Chong
Zhao, Changsheng
Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title_full Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title_fullStr Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title_full_unstemmed Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title_short Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
title_sort hedgehog artificial macrophage with atomic-catalytic centers to combat drug-resistant bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536674/
https://www.ncbi.nlm.nih.gov/pubmed/34686676
http://dx.doi.org/10.1038/s41467-021-26456-9
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