Cargando…

Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants

We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth w...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lingping, Yang, Liu, Dong, Wenbin, Liu, Xingling, Lei, Xiaoping, Zhang, Lianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536761/
https://www.ncbi.nlm.nih.gov/pubmed/34686686
http://dx.doi.org/10.1038/s41598-021-00120-0
_version_ 1784588091080572928
author Zhang, Lingping
Yang, Liu
Dong, Wenbin
Liu, Xingling
Lei, Xiaoping
Zhang, Lianyu
author_facet Zhang, Lingping
Yang, Liu
Dong, Wenbin
Liu, Xingling
Lei, Xiaoping
Zhang, Lianyu
author_sort Zhang, Lingping
collection PubMed
description We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth weight < 1500 g. The demographics, PICC-related characteristics, and treatment information were collected. Univariate and multivariate analyses were performed to investigate risk factors for PICC-related fungal colonization. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off values for the duration of antibiotics and parenteral nutrition. In total, 124 premature infants underwent PICC insertion. Among them, 19 patients had positive results of fungi on the PICC tips. The duration of antibiotics (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02–1.31), parenteral nutrition infusion (OR 1.27, 95% CI 1.05–1.54), and postnatal glucocorticoid exposure (OR 9.48, 95% CI 1.06–84.98) were independent risk factors for fungal colonization in PICCs. The ROC curves showed that the risk increased after 15 days of antibiotic use and 28 days of parenteral nutrition infusion. Appropriate clinical management should be used to prevent fungal colonization and fungemia.
format Online
Article
Text
id pubmed-8536761
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-85367612021-10-25 Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants Zhang, Lingping Yang, Liu Dong, Wenbin Liu, Xingling Lei, Xiaoping Zhang, Lianyu Sci Rep Article We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth weight < 1500 g. The demographics, PICC-related characteristics, and treatment information were collected. Univariate and multivariate analyses were performed to investigate risk factors for PICC-related fungal colonization. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off values for the duration of antibiotics and parenteral nutrition. In total, 124 premature infants underwent PICC insertion. Among them, 19 patients had positive results of fungi on the PICC tips. The duration of antibiotics (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02–1.31), parenteral nutrition infusion (OR 1.27, 95% CI 1.05–1.54), and postnatal glucocorticoid exposure (OR 9.48, 95% CI 1.06–84.98) were independent risk factors for fungal colonization in PICCs. The ROC curves showed that the risk increased after 15 days of antibiotic use and 28 days of parenteral nutrition infusion. Appropriate clinical management should be used to prevent fungal colonization and fungemia. Nature Publishing Group UK 2021-10-22 /pmc/articles/PMC8536761/ /pubmed/34686686 http://dx.doi.org/10.1038/s41598-021-00120-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Lingping
Yang, Liu
Dong, Wenbin
Liu, Xingling
Lei, Xiaoping
Zhang, Lianyu
Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title_full Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title_fullStr Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title_full_unstemmed Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title_short Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
title_sort risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536761/
https://www.ncbi.nlm.nih.gov/pubmed/34686686
http://dx.doi.org/10.1038/s41598-021-00120-0
work_keys_str_mv AT zhanglingping riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants
AT yangliu riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants
AT dongwenbin riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants
AT liuxingling riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants
AT leixiaoping riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants
AT zhanglianyu riskfactorsandclinicalanalysisofperipherallyinsertedcentralcatheterrelatedfungalcolonizationinprematureinfants