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Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants
We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536761/ https://www.ncbi.nlm.nih.gov/pubmed/34686686 http://dx.doi.org/10.1038/s41598-021-00120-0 |
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author | Zhang, Lingping Yang, Liu Dong, Wenbin Liu, Xingling Lei, Xiaoping Zhang, Lianyu |
author_facet | Zhang, Lingping Yang, Liu Dong, Wenbin Liu, Xingling Lei, Xiaoping Zhang, Lianyu |
author_sort | Zhang, Lingping |
collection | PubMed |
description | We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth weight < 1500 g. The demographics, PICC-related characteristics, and treatment information were collected. Univariate and multivariate analyses were performed to investigate risk factors for PICC-related fungal colonization. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off values for the duration of antibiotics and parenteral nutrition. In total, 124 premature infants underwent PICC insertion. Among them, 19 patients had positive results of fungi on the PICC tips. The duration of antibiotics (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02–1.31), parenteral nutrition infusion (OR 1.27, 95% CI 1.05–1.54), and postnatal glucocorticoid exposure (OR 9.48, 95% CI 1.06–84.98) were independent risk factors for fungal colonization in PICCs. The ROC curves showed that the risk increased after 15 days of antibiotic use and 28 days of parenteral nutrition infusion. Appropriate clinical management should be used to prevent fungal colonization and fungemia. |
format | Online Article Text |
id | pubmed-8536761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85367612021-10-25 Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants Zhang, Lingping Yang, Liu Dong, Wenbin Liu, Xingling Lei, Xiaoping Zhang, Lianyu Sci Rep Article We aimed to analyze the risk factors of positive peripherally inserted central catheter (PICC)-related fungal colonization in preterm infants. This retrospective study collected data from 2018 to 2020. The enrolled infants who underwent PICC insertion were born at < 32 weeks’ gestation or birth weight < 1500 g. The demographics, PICC-related characteristics, and treatment information were collected. Univariate and multivariate analyses were performed to investigate risk factors for PICC-related fungal colonization. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off values for the duration of antibiotics and parenteral nutrition. In total, 124 premature infants underwent PICC insertion. Among them, 19 patients had positive results of fungi on the PICC tips. The duration of antibiotics (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02–1.31), parenteral nutrition infusion (OR 1.27, 95% CI 1.05–1.54), and postnatal glucocorticoid exposure (OR 9.48, 95% CI 1.06–84.98) were independent risk factors for fungal colonization in PICCs. The ROC curves showed that the risk increased after 15 days of antibiotic use and 28 days of parenteral nutrition infusion. Appropriate clinical management should be used to prevent fungal colonization and fungemia. Nature Publishing Group UK 2021-10-22 /pmc/articles/PMC8536761/ /pubmed/34686686 http://dx.doi.org/10.1038/s41598-021-00120-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Lingping Yang, Liu Dong, Wenbin Liu, Xingling Lei, Xiaoping Zhang, Lianyu Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title | Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title_full | Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title_fullStr | Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title_full_unstemmed | Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title_short | Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
title_sort | risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536761/ https://www.ncbi.nlm.nih.gov/pubmed/34686686 http://dx.doi.org/10.1038/s41598-021-00120-0 |
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