Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et)...

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Autores principales: Wu, Luyan, Ishigaki, Yusuke, Zeng, Wenhui, Harimoto, Takashi, Yin, Baoli, Chen, Yinghan, Liao, Shiyi, Liu, Yongchun, Sun, Yidan, Zhang, Xiaobo, Liu, Ying, Liang, Yong, Sun, Pengfei, Suzuki, Takanori, Song, Guosheng, Fan, Quli, Ye, Deju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536768/
https://www.ncbi.nlm.nih.gov/pubmed/34686685
http://dx.doi.org/10.1038/s41467-021-26380-y
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author Wu, Luyan
Ishigaki, Yusuke
Zeng, Wenhui
Harimoto, Takashi
Yin, Baoli
Chen, Yinghan
Liao, Shiyi
Liu, Yongchun
Sun, Yidan
Zhang, Xiaobo
Liu, Ying
Liang, Yong
Sun, Pengfei
Suzuki, Takanori
Song, Guosheng
Fan, Quli
Ye, Deju
author_facet Wu, Luyan
Ishigaki, Yusuke
Zeng, Wenhui
Harimoto, Takashi
Yin, Baoli
Chen, Yinghan
Liao, Shiyi
Liu, Yongchun
Sun, Yidan
Zhang, Xiaobo
Liu, Ying
Liang, Yong
Sun, Pengfei
Suzuki, Takanori
Song, Guosheng
Fan, Quli
Ye, Deju
author_sort Wu, Luyan
collection PubMed
description Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL(780)/FL(1113)), but a small PA ratio between 755 and 905 nm (PA(755)/PA(905)). Oxidation of 1-Br-Et by •OH decreases the FL(780)/FL(1113) while concurrently increasing the PA(755)/PA(905), allowing the reliable monitoring of •OH production in tumors undergoing erastin-induced ferroptosis or radiotherapy.
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spelling pubmed-85367682021-11-15 Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy Wu, Luyan Ishigaki, Yusuke Zeng, Wenhui Harimoto, Takashi Yin, Baoli Chen, Yinghan Liao, Shiyi Liu, Yongchun Sun, Yidan Zhang, Xiaobo Liu, Ying Liang, Yong Sun, Pengfei Suzuki, Takanori Song, Guosheng Fan, Quli Ye, Deju Nat Commun Article Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL(780)/FL(1113)), but a small PA ratio between 755 and 905 nm (PA(755)/PA(905)). Oxidation of 1-Br-Et by •OH decreases the FL(780)/FL(1113) while concurrently increasing the PA(755)/PA(905), allowing the reliable monitoring of •OH production in tumors undergoing erastin-induced ferroptosis or radiotherapy. Nature Publishing Group UK 2021-10-22 /pmc/articles/PMC8536768/ /pubmed/34686685 http://dx.doi.org/10.1038/s41467-021-26380-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wu, Luyan
Ishigaki, Yusuke
Zeng, Wenhui
Harimoto, Takashi
Yin, Baoli
Chen, Yinghan
Liao, Shiyi
Liu, Yongchun
Sun, Yidan
Zhang, Xiaobo
Liu, Ying
Liang, Yong
Sun, Pengfei
Suzuki, Takanori
Song, Guosheng
Fan, Quli
Ye, Deju
Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title_full Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title_fullStr Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title_full_unstemmed Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title_short Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
title_sort generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536768/
https://www.ncbi.nlm.nih.gov/pubmed/34686685
http://dx.doi.org/10.1038/s41467-021-26380-y
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