COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Demonbreun, Alexis R, Sancilio, Amelia, Velez, Matt E, Ryan, Daniel T, Pesce, Lorenzo, Saber, Rana, Vaught, Lauren A, Reiser, Nina L, Hsieh, Ryan R, D’Aquila, Richard T, Mustanski, Brian, McDade, Thomas W, McNally, Elizabeth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536925/
https://www.ncbi.nlm.nih.gov/pubmed/34117873
http://dx.doi.org/10.1093/infdis/jiab314
Descripción
Sumario:We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.

Ejemplares similares