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A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present recent studies on the use of electrospun nanofiber-bas...

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Detalles Bibliográficos
Autores principales: Omer, Safaa, Zelkó, Romána
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536958/
https://www.ncbi.nlm.nih.gov/pubmed/34683930
http://dx.doi.org/10.3390/pharmaceutics13101637
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author Omer, Safaa
Zelkó, Romána
author_facet Omer, Safaa
Zelkó, Romána
author_sort Omer, Safaa
collection PubMed
description Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present recent studies on the use of electrospun nanofiber-based ocular inserts to improve the bioavailability of drugs used for different ophthalmic diseases. A systematic search was performed in PubMed, Ovid Medline, Web of Science, ScienceDirect, Scopus, Reaxys, Google Scholar, and Google Patents/Espacenet taking “drug-loaded”, “nanofibers”, and “ophthalmic inserts” and their equivalent terms as keywords. The search was limited to original and peer-reviewed studies published in 2011–2021 in English language. Only 13 out of 795 articles and 15 out of 197 patents were included. All results revealed the success of nanofiber-based ocular inserts in targeting and improved bioavailability. Ocular inserts based on nanofibers can be used as safe, efficient carriers for the treatment of anterior and posterior eye diseases.
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spelling pubmed-85369582021-10-24 A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts Omer, Safaa Zelkó, Romána Pharmaceutics Review Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present recent studies on the use of electrospun nanofiber-based ocular inserts to improve the bioavailability of drugs used for different ophthalmic diseases. A systematic search was performed in PubMed, Ovid Medline, Web of Science, ScienceDirect, Scopus, Reaxys, Google Scholar, and Google Patents/Espacenet taking “drug-loaded”, “nanofibers”, and “ophthalmic inserts” and their equivalent terms as keywords. The search was limited to original and peer-reviewed studies published in 2011–2021 in English language. Only 13 out of 795 articles and 15 out of 197 patents were included. All results revealed the success of nanofiber-based ocular inserts in targeting and improved bioavailability. Ocular inserts based on nanofibers can be used as safe, efficient carriers for the treatment of anterior and posterior eye diseases. MDPI 2021-10-08 /pmc/articles/PMC8536958/ /pubmed/34683930 http://dx.doi.org/10.3390/pharmaceutics13101637 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Omer, Safaa
Zelkó, Romána
A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title_full A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title_fullStr A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title_full_unstemmed A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title_short A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts
title_sort systematic review of drug-loaded electrospun nanofiber-based ophthalmic inserts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536958/
https://www.ncbi.nlm.nih.gov/pubmed/34683930
http://dx.doi.org/10.3390/pharmaceutics13101637
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