Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose

Initial seizures observed in young rats during the 60 min after administration of pilocarpine (Pilo) were delayed and attenuated by pretreatment with a non-convulsive dose of methionine sulfoximine (MSO). We hypothesized that the effect of MSO results from a) glutamine synthetase block-mediated inhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pawlik, Marek J., Aldana, Blanca I., Belfiori-Carrasco, Lautaro F., Obara-Michlewska, Marta, Popek, Mariusz P., Czarnecka, Anna Maria, Albrecht, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536987/
https://www.ncbi.nlm.nih.gov/pubmed/34681786
http://dx.doi.org/10.3390/ijms222011127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536987/
https://www.ncbi.nlm.nih.gov/pubmed/34681786
http://dx.doi.org/10.3390/ijms222011127

Ejemplares similares