Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions

INDY (I’m Not Dead Yet) is a plasma membrane transporter for citrate, first identified in Drosophila. Partial deficiency of INDY extends lifespan in this organism in a manner similar to that of caloric restriction. The mammalian counterpart (NaCT/SLC13A5) also transports citrate. In mice, it is the...

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Detalles Bibliográficos
Autores principales: Jaramillo-Martinez, Valeria, Sivaprakasam, Sathish, Ganapathy, Vadivel, Urbatsch, Ina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537002/
https://www.ncbi.nlm.nih.gov/pubmed/34677384
http://dx.doi.org/10.3390/metabo11100669

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