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Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis

Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-tran...

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Autores principales: Zhu, Jun, Inomata, Takenori, Di Zazzo, Antonio, Kitazawa, Koji, Okumura, Yuichi, Coassin, Marco, Surico, Pier Luigi, Fujio, Kenta, Yanagawa, Ai, Miura, Maria, Akasaki, Yasutsugu, Fujimoto, Keiichi, Nagino, Ken, Midorikawa-Inomata, Akie, Hirosawa, Kunihiko, Kuwahara, Mizu, Huang, Tianxiang, Shokirova, Hurramhon, Eguchi, Atsuko, Murakami, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537034/
https://www.ncbi.nlm.nih.gov/pubmed/34682792
http://dx.doi.org/10.3390/jcm10204667
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author Zhu, Jun
Inomata, Takenori
Di Zazzo, Antonio
Kitazawa, Koji
Okumura, Yuichi
Coassin, Marco
Surico, Pier Luigi
Fujio, Kenta
Yanagawa, Ai
Miura, Maria
Akasaki, Yasutsugu
Fujimoto, Keiichi
Nagino, Ken
Midorikawa-Inomata, Akie
Hirosawa, Kunihiko
Kuwahara, Mizu
Huang, Tianxiang
Shokirova, Hurramhon
Eguchi, Atsuko
Murakami, Akira
author_facet Zhu, Jun
Inomata, Takenori
Di Zazzo, Antonio
Kitazawa, Koji
Okumura, Yuichi
Coassin, Marco
Surico, Pier Luigi
Fujio, Kenta
Yanagawa, Ai
Miura, Maria
Akasaki, Yasutsugu
Fujimoto, Keiichi
Nagino, Ken
Midorikawa-Inomata, Akie
Hirosawa, Kunihiko
Kuwahara, Mizu
Huang, Tianxiang
Shokirova, Hurramhon
Eguchi, Atsuko
Murakami, Akira
author_sort Zhu, Jun
collection PubMed
description Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival.
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spelling pubmed-85370342021-10-24 Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis Zhu, Jun Inomata, Takenori Di Zazzo, Antonio Kitazawa, Koji Okumura, Yuichi Coassin, Marco Surico, Pier Luigi Fujio, Kenta Yanagawa, Ai Miura, Maria Akasaki, Yasutsugu Fujimoto, Keiichi Nagino, Ken Midorikawa-Inomata, Akie Hirosawa, Kunihiko Kuwahara, Mizu Huang, Tianxiang Shokirova, Hurramhon Eguchi, Atsuko Murakami, Akira J Clin Med Review Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival. MDPI 2021-10-12 /pmc/articles/PMC8537034/ /pubmed/34682792 http://dx.doi.org/10.3390/jcm10204667 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Jun
Inomata, Takenori
Di Zazzo, Antonio
Kitazawa, Koji
Okumura, Yuichi
Coassin, Marco
Surico, Pier Luigi
Fujio, Kenta
Yanagawa, Ai
Miura, Maria
Akasaki, Yasutsugu
Fujimoto, Keiichi
Nagino, Ken
Midorikawa-Inomata, Akie
Hirosawa, Kunihiko
Kuwahara, Mizu
Huang, Tianxiang
Shokirova, Hurramhon
Eguchi, Atsuko
Murakami, Akira
Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title_full Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title_fullStr Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title_full_unstemmed Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title_short Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
title_sort role of immune cell diversity and heterogeneity in corneal graft survival: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537034/
https://www.ncbi.nlm.nih.gov/pubmed/34682792
http://dx.doi.org/10.3390/jcm10204667
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