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Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-tran...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537034/ https://www.ncbi.nlm.nih.gov/pubmed/34682792 http://dx.doi.org/10.3390/jcm10204667 |
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author | Zhu, Jun Inomata, Takenori Di Zazzo, Antonio Kitazawa, Koji Okumura, Yuichi Coassin, Marco Surico, Pier Luigi Fujio, Kenta Yanagawa, Ai Miura, Maria Akasaki, Yasutsugu Fujimoto, Keiichi Nagino, Ken Midorikawa-Inomata, Akie Hirosawa, Kunihiko Kuwahara, Mizu Huang, Tianxiang Shokirova, Hurramhon Eguchi, Atsuko Murakami, Akira |
author_facet | Zhu, Jun Inomata, Takenori Di Zazzo, Antonio Kitazawa, Koji Okumura, Yuichi Coassin, Marco Surico, Pier Luigi Fujio, Kenta Yanagawa, Ai Miura, Maria Akasaki, Yasutsugu Fujimoto, Keiichi Nagino, Ken Midorikawa-Inomata, Akie Hirosawa, Kunihiko Kuwahara, Mizu Huang, Tianxiang Shokirova, Hurramhon Eguchi, Atsuko Murakami, Akira |
author_sort | Zhu, Jun |
collection | PubMed |
description | Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival. |
format | Online Article Text |
id | pubmed-8537034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85370342021-10-24 Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis Zhu, Jun Inomata, Takenori Di Zazzo, Antonio Kitazawa, Koji Okumura, Yuichi Coassin, Marco Surico, Pier Luigi Fujio, Kenta Yanagawa, Ai Miura, Maria Akasaki, Yasutsugu Fujimoto, Keiichi Nagino, Ken Midorikawa-Inomata, Akie Hirosawa, Kunihiko Kuwahara, Mizu Huang, Tianxiang Shokirova, Hurramhon Eguchi, Atsuko Murakami, Akira J Clin Med Review Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival. MDPI 2021-10-12 /pmc/articles/PMC8537034/ /pubmed/34682792 http://dx.doi.org/10.3390/jcm10204667 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhu, Jun Inomata, Takenori Di Zazzo, Antonio Kitazawa, Koji Okumura, Yuichi Coassin, Marco Surico, Pier Luigi Fujio, Kenta Yanagawa, Ai Miura, Maria Akasaki, Yasutsugu Fujimoto, Keiichi Nagino, Ken Midorikawa-Inomata, Akie Hirosawa, Kunihiko Kuwahara, Mizu Huang, Tianxiang Shokirova, Hurramhon Eguchi, Atsuko Murakami, Akira Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title | Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title_full | Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title_fullStr | Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title_short | Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis |
title_sort | role of immune cell diversity and heterogeneity in corneal graft survival: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537034/ https://www.ncbi.nlm.nih.gov/pubmed/34682792 http://dx.doi.org/10.3390/jcm10204667 |
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