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Elucidating Carfilzomib’s Induced Cardiotoxicity in an In Vivo Model of Aging: Prophylactic Potential of Metformin

Background: Carfilzomib is a first-line proteasome inhibitor indicated for relapsed/refractory multiple myeloma (MM), with its clinical use being hampered by cardiotoxic phenomena. We have previously established a translational model of carfilzomib cardiotoxicity in young adult mice, in which metfor...

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Detalles Bibliográficos
Autores principales:	Efentakis, Panagiotis, Psarakou, Garyfalia, Varela, Aimilia, Papanagnou, Eleni Dimitra, Chatzistefanou, Michail, Nikolaou, Panagiota-Efstathia, Davos, Costantinos H., Gavriatopoulou, Maria, Trougakos, Ioannis P., Dimopoulos, Meletios Athanasios, Andreadou, Ioanna, Terpos, Evangelos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537073/ https://www.ncbi.nlm.nih.gov/pubmed/34681615 http://dx.doi.org/10.3390/ijms222010956

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