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Selection of Pneumocystis jirovecii Inosine 5′-Monophosphate Dehydrogenase Mutants in Solid Organ Transplant Recipients: Implication of Mycophenolic Acid

Mycophenolic acid (MPA) targets the inosine 5′-monophosphate dehydrogenase (IMPDH) of human lymphocytes. It is widely used as an immunosuppressant to prevent rejection in solid organ transplant (SOT) recipients who, incidentally, are at risk for Pneumocystis pneumonia (PCP). We hypothesized that MPA...

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Detalles Bibliográficos
Autores principales:	Hoffmann, Claire V., Nevez, Gilles, Moal, Marie-Christine, Quinio, Dorothée, Le Nan, Nathan, Papon, Nicolas, Bouchara, Jean-Philippe, Le Meur, Yannick, Le Gal, Solène
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537117/ https://www.ncbi.nlm.nih.gov/pubmed/34682270 http://dx.doi.org/10.3390/jof7100849

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