Cargando…

Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan

Exposure to Libby amphibole (LA) asbestos-like fibers is associated with increased risk of asbestosis, mesothelioma, pulmonary disease, and systemic autoimmune disease. LGM2605 is a small molecule antioxidant and free radical scavenger, with anti-inflammatory effects in various disease models. The c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Badger, Reagan, Park, Kyewon, Pietrofesa, Ralph A., Christofidou-Solomidou, Melpo, Serve, Kinta M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537122/ https://www.ncbi.nlm.nih.gov/pubmed/34681644 http://dx.doi.org/10.3390/ijms222010982

Ejemplares similares

Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner
por: Pietrofesa, Ralph A., et al.
Publicado: (2018)

Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia
por: Dhingra, Anuradha, et al.
Publicado: (2021)

Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605)
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages
por: Pietrofesa, Ralph A., et al.
Publicado: (2017)

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage
por: Velalopoulou, Anastasia, et al.
Publicado: (2015)

Short‐term exposure to synthetic flaxseed lignan LGM2605 alters gut microbiota in mice
por: Badger, Reagan, et al.
Publicado: (2021)

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

Radiation mitigating properties of the lignan component in flaxseed
por: Pietrofesa, Ralph, et al.
Publicado: (2013)

Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy
por: Kartha, Sonia, et al.
Publicado: (2020)

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells
por: Pietrofesa, Ralph A., et al.
Publicado: (2022)

Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605)
por: Pietrofesa, Ralph A., et al.
Publicado: (2021)

Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection
por: Mishra, Om P., et al.
Publicado: (2016)

LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks
por: Chatterjee, Shampa, et al.
Publicado: (2019)

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study
por: Turowski, Jason B, et al.
Publicado: (2015)

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage
por: Velalopoulou, Anastasia, et al.
Publicado: (2017)

Analyses of amphibole asbestiform fibers in municipal water supplies
por: Nicholson, William J.
Publicado: (1974)

Oxidative Stress and Space Biology: An Organ-Based Approach
por: Goodwin, Thomas J., et al.
Publicado: (2018)

Editorial to the Special Issue: “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment”
por: Goodwin, Thomas J., et al.
Publicado: (2022)

Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
por: Dukes, Floyd, et al.
Publicado: (2012)

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice
por: Christofidou-Solomidou, Melpo, et al.
Publicado: (2011)

Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

Diagnostic and Prognostic Value of Three microRNAs in Environmental Asbestiform Fibers-Associated Malignant Mesothelioma
por: Filetti, Veronica, et al.
Publicado: (2021)

Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines
por: Chikara, Shireen, et al.
Publicado: (2017)

Defense and protection mechanisms in lung exposed to asbestiform fiber: The role of macrophage migration inhibitory factor and heme oxygenase-1
por: Loreto, Carla, et al.
Publicado: (2020)

Dysregulation of microRNAs and tRNA-derived ncRNAs in mesothelial and mesothelioma cell lines after asbestiform fiber exposure
por: Filetti, Veronica, et al.
Publicado: (2022)

An Evaluation of Potential Occupational Exposure to Asbestiform Amphiboles near a Former Vermiculite Mine
por: Hart, Julie F., et al.
Publicado: (2009)

Pathogenic Potential of Respirable Spodumene Cleavage Fragments following Application of Regulatory Counting Criteria for Asbestiform Fibres
por: Gardner, Melinda, et al.
Publicado: (2022)

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
por: Rom, Slava, et al.
Publicado: (2018)

Lignans
por: Barker, David
Publicado: (2019)

Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation
por: Berman, Abigail T, et al.
Publicado: (2013)

Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines
por: Xue, Lijuan, et al.
Publicado: (2023)

Carving of non-asbestiform tremolite and the risk of lung cancer: a follow-up mortality study in a historical nephrite processing cohort
por: Yang, Hsiao-Yu, et al.
Publicado: (2013)

Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo
por: Shuvaev, Vladimir V., et al.
Publicado: (2013)

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease
por: Linder, Thomas, et al.
Publicado: (2019)

Oxidative Transformations of Lignans
por: Runeberg, Patrik A., et al.
Publicado: (2019)

NMR Characterization of Lignans
por: Consonni, Roberto, et al.
Publicado: (2022)

Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata
por: Yokosuka, Akihito, et al.
Publicado: (2021)

Lignans: A Chemometric Analysis
por: Pilkington, Lisa I.
Publicado: (2018)

Hinokinin, an Emerging Bioactive Lignan
por: Marcotullio, Maria Carla, et al.
Publicado: (2014)

Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta
por: Chen, Min, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ml9l0vggn5e7qnl3jf9o235bp2