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Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population

The rs7041 and rs4588 polymorphisms found in the GC gene, encoding vitamin D-binding protein (DBP), have distinct biochemical phenotypes. The aim of this study was to investigate vitamin D parameters with these polymorphisms, in individuals with possible vitamin D deficiency. The most common (49% of...

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Autores principales: Karcıoğlu Batur, Lutfiye, Özaydın, Ahmet, Maviş, Murat Emrah, Gürsu, Gökçe Göksu, Harbige, Laurence, Hekim, Nezih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537126/
https://www.ncbi.nlm.nih.gov/pubmed/34677411
http://dx.doi.org/10.3390/metabo11100696
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author Karcıoğlu Batur, Lutfiye
Özaydın, Ahmet
Maviş, Murat Emrah
Gürsu, Gökçe Göksu
Harbige, Laurence
Hekim, Nezih
author_facet Karcıoğlu Batur, Lutfiye
Özaydın, Ahmet
Maviş, Murat Emrah
Gürsu, Gökçe Göksu
Harbige, Laurence
Hekim, Nezih
author_sort Karcıoğlu Batur, Lutfiye
collection PubMed
description The rs7041 and rs4588 polymorphisms found in the GC gene, encoding vitamin D-binding protein (DBP), have distinct biochemical phenotypes. The aim of this study was to investigate vitamin D parameters with these polymorphisms, in individuals with possible vitamin D deficiency. The most common (49% of the cohort) genotype in rs7041 was GT, especially among individuals with high levels of free 25(OH)D calculated but with low levels of bioavailable 25(OH)D, and in rs4588 it was AC in particular among the individuals with low levels of bioavailable 25(OH)D. The most common phenotypes were Gc1s/2 (35.3%) and Gc1s/1s (31.4%), and Gc1f/1f was rare (5.9%). The variations in free and bioavailable 25(OH)D levels among healthy Turkish individuals may be attributed to the variations in total 25(OH)D as well as GC gene polymorphisms. The Turkish population shares a similarity for allele frequencies of rs7041 with the European population and similarity for allele frequencies of rs4588 with Gujarati Indians, and this may also be important in relation to certain ethnic populations showing associations between vitamin D and COVID-19.
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spelling pubmed-85371262021-10-24 Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population Karcıoğlu Batur, Lutfiye Özaydın, Ahmet Maviş, Murat Emrah Gürsu, Gökçe Göksu Harbige, Laurence Hekim, Nezih Metabolites Article The rs7041 and rs4588 polymorphisms found in the GC gene, encoding vitamin D-binding protein (DBP), have distinct biochemical phenotypes. The aim of this study was to investigate vitamin D parameters with these polymorphisms, in individuals with possible vitamin D deficiency. The most common (49% of the cohort) genotype in rs7041 was GT, especially among individuals with high levels of free 25(OH)D calculated but with low levels of bioavailable 25(OH)D, and in rs4588 it was AC in particular among the individuals with low levels of bioavailable 25(OH)D. The most common phenotypes were Gc1s/2 (35.3%) and Gc1s/1s (31.4%), and Gc1f/1f was rare (5.9%). The variations in free and bioavailable 25(OH)D levels among healthy Turkish individuals may be attributed to the variations in total 25(OH)D as well as GC gene polymorphisms. The Turkish population shares a similarity for allele frequencies of rs7041 with the European population and similarity for allele frequencies of rs4588 with Gujarati Indians, and this may also be important in relation to certain ethnic populations showing associations between vitamin D and COVID-19. MDPI 2021-10-12 /pmc/articles/PMC8537126/ /pubmed/34677411 http://dx.doi.org/10.3390/metabo11100696 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karcıoğlu Batur, Lutfiye
Özaydın, Ahmet
Maviş, Murat Emrah
Gürsu, Gökçe Göksu
Harbige, Laurence
Hekim, Nezih
Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title_full Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title_fullStr Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title_full_unstemmed Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title_short Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
title_sort vitamin-d binding protein gene polymorphisms and serum 25-hydroxyvitamin-d in a turkish population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537126/
https://www.ncbi.nlm.nih.gov/pubmed/34677411
http://dx.doi.org/10.3390/metabo11100696
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