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The Role of the Noradrenergic System in Eating Disorders: A Systematic Review

Noradrenaline (NE) is a catecholamine acting as both a neurotransmitter and a hormone, with relevant effects in modulating feeding behavior and satiety. Several studies have assessed the relationship between the noradrenergic system and Eating Disorders (EDs). This systematic review aims to report t...

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Autores principales: Pruccoli, Jacopo, Parmeggiani, Antonia, Cordelli, Duccio Maria, Lanari, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537146/
https://www.ncbi.nlm.nih.gov/pubmed/34681746
http://dx.doi.org/10.3390/ijms222011086
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author Pruccoli, Jacopo
Parmeggiani, Antonia
Cordelli, Duccio Maria
Lanari, Marcello
author_facet Pruccoli, Jacopo
Parmeggiani, Antonia
Cordelli, Duccio Maria
Lanari, Marcello
author_sort Pruccoli, Jacopo
collection PubMed
description Noradrenaline (NE) is a catecholamine acting as both a neurotransmitter and a hormone, with relevant effects in modulating feeding behavior and satiety. Several studies have assessed the relationship between the noradrenergic system and Eating Disorders (EDs). This systematic review aims to report the existing literature on the role of the noradrenergic system in the development and treatment of EDs. A total of 35 studies were included. Preclinical studies demonstrated an involvement of the noradrenergic pathways in binge-like behaviors. Genetic studies on polymorphisms in genes coding for NE transporters and regulating enzymes have shown conflicting evidence. Clinical studies have reported non-unanimous evidence for the existence of absolute alterations in plasma NE values in patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Pharmacological studies have documented the efficacy of noradrenaline-modulating therapies in the treatment of BN and Binge Eating Disorder (BED). Insufficient evidence was found concerning the noradrenergic-mediated genetics of BED and BN, and psychopharmacological treatments targeting the noradrenergic system in AN. According to these data, further studies are required to expand the existing knowledge on the noradrenergic system as a potential target for treatments of EDs.
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spelling pubmed-85371462021-10-24 The Role of the Noradrenergic System in Eating Disorders: A Systematic Review Pruccoli, Jacopo Parmeggiani, Antonia Cordelli, Duccio Maria Lanari, Marcello Int J Mol Sci Systematic Review Noradrenaline (NE) is a catecholamine acting as both a neurotransmitter and a hormone, with relevant effects in modulating feeding behavior and satiety. Several studies have assessed the relationship between the noradrenergic system and Eating Disorders (EDs). This systematic review aims to report the existing literature on the role of the noradrenergic system in the development and treatment of EDs. A total of 35 studies were included. Preclinical studies demonstrated an involvement of the noradrenergic pathways in binge-like behaviors. Genetic studies on polymorphisms in genes coding for NE transporters and regulating enzymes have shown conflicting evidence. Clinical studies have reported non-unanimous evidence for the existence of absolute alterations in plasma NE values in patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Pharmacological studies have documented the efficacy of noradrenaline-modulating therapies in the treatment of BN and Binge Eating Disorder (BED). Insufficient evidence was found concerning the noradrenergic-mediated genetics of BED and BN, and psychopharmacological treatments targeting the noradrenergic system in AN. According to these data, further studies are required to expand the existing knowledge on the noradrenergic system as a potential target for treatments of EDs. MDPI 2021-10-14 /pmc/articles/PMC8537146/ /pubmed/34681746 http://dx.doi.org/10.3390/ijms222011086 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Pruccoli, Jacopo
Parmeggiani, Antonia
Cordelli, Duccio Maria
Lanari, Marcello
The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title_full The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title_fullStr The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title_full_unstemmed The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title_short The Role of the Noradrenergic System in Eating Disorders: A Systematic Review
title_sort role of the noradrenergic system in eating disorders: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537146/
https://www.ncbi.nlm.nih.gov/pubmed/34681746
http://dx.doi.org/10.3390/ijms222011086
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