Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

Four new anthraquinone derivatives, namely saliniquinones G−I (1–3) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including abs...

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Autores principales: Zhou, Luning, Chen, Xuedong, Sun, Chunxiao, Chang, Yimin, Huang, Xiaofei, Zhu, Tianjiao, Zhang, Guojian, Che, Qian, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537165/
https://www.ncbi.nlm.nih.gov/pubmed/34677474
http://dx.doi.org/10.3390/md19100575
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author Zhou, Luning
Chen, Xuedong
Sun, Chunxiao
Chang, Yimin
Huang, Xiaofei
Zhu, Tianjiao
Zhang, Guojian
Che, Qian
Li, Dehai
author_facet Zhou, Luning
Chen, Xuedong
Sun, Chunxiao
Chang, Yimin
Huang, Xiaofei
Zhu, Tianjiao
Zhang, Guojian
Che, Qian
Li, Dehai
author_sort Zhou, Luning
collection PubMed
description Four new anthraquinone derivatives, namely saliniquinones G−I (1–3) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.
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spelling pubmed-85371652021-10-24 Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252 Zhou, Luning Chen, Xuedong Sun, Chunxiao Chang, Yimin Huang, Xiaofei Zhu, Tianjiao Zhang, Guojian Che, Qian Li, Dehai Mar Drugs Article Four new anthraquinone derivatives, namely saliniquinones G−I (1–3) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM. MDPI 2021-10-14 /pmc/articles/PMC8537165/ /pubmed/34677474 http://dx.doi.org/10.3390/md19100575 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Luning
Chen, Xuedong
Sun, Chunxiao
Chang, Yimin
Huang, Xiaofei
Zhu, Tianjiao
Zhang, Guojian
Che, Qian
Li, Dehai
Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title_full Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title_fullStr Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title_full_unstemmed Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title_short Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252
title_sort saliniquinone derivatives, saliniquinones g−i and heraclemycin e, from the marine animal-derived nocardiopsis aegyptia hdn19-252
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537165/
https://www.ncbi.nlm.nih.gov/pubmed/34677474
http://dx.doi.org/10.3390/md19100575
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