Cargando…

The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives

Accumulating evidence suggests the key role of the kynurenine pathway (KP) of the tryptophan metabolism in the pathogenesis of several diseases. Despite extensive research aimed at clarifying the mechanisms underlying the development and maintenance of neuropathic pain, the roles of KP metabolites i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ciapała, Katarzyna, Mika, Joanna, Rojewska, Ewelina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537209/ https://www.ncbi.nlm.nih.gov/pubmed/34681715 http://dx.doi.org/10.3390/ijms222011055

Ejemplares similares

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
por: Rojewska, Ewelina, et al.
Publicado: (2018)

Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2021)

Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain
por: Ciapała, Katarzyna, et al.
Publicado: (2023)

Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—In Vivo and In Vitro Study
por: Piotrowska, Anna, et al.
Publicado: (2021)

Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics
por: Ciapała, Katarzyna, et al.
Publicado: (2023)

Mirogabalin Decreases Pain-like Behaviours and Improves Opioid and Ketamine Antinociception in a Mouse Model of Neuropathic Pain
por: Zajączkowska, Renata, et al.
Publicado: (2022)

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies
por: Ciechanowska, Agata, et al.
Publicado: (2022)

Botulinum Toxin Type A—A Modulator of Spinal Neuron–Glia Interactions under Neuropathic Pain Conditions
por: Rojewska, Ewelina, et al.
Publicado: (2018)

Mirogabalin Decreases Pain-like Behaviors by Inhibiting the Microglial/Macrophage Activation, p38MAPK Signaling, and Pronociceptive CCL2 and CCL5 Release in a Mouse Model of Neuropathic Pain
por: Zajączkowska, Renata, et al.
Publicado: (2023)

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain
por: Mika, Joanna, et al.
Publicado: (2014)

Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain
por: Rojewska, Ewelina, et al.
Publicado: (2014)

Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
por: Piotrowska, Anna, et al.
Publicado: (2018)

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain
por: Zajaczkowska, Renata, et al.
Publicado: (2020)

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2014)

Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems
por: Wawrzczak-Bargieła, Agnieszka, et al.
Publicado: (2020)

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model
por: Jurga, Agnieszka M., et al.
Publicado: (2016)

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2016)

Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence from a Mouse Model
por: Ciechanowska, Agata, et al.
Publicado: (2023)

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats
por: Kwiatkowski, Klaudia, et al.
Publicado: (2017)

Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury
por: Piotrowska, Anna, et al.
Publicado: (2019)

Phenytoin Decreases Pain-like Behaviors and Improves Opioid Analgesia in a Rat Model of Neuropathic Pain
por: Kocot-Kępska, Magdalena, et al.
Publicado: (2023)

Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2022)

Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice
por: Maganin, Alexandre G., et al.
Publicado: (2022)

CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain
por: Bogacka, Joanna, et al.
Publicado: (2020)

Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2023)

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies
por: Shinoda, Masamichi, et al.
Publicado: (2021)

Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain
por: Staats Pires, Ananda, et al.
Publicado: (2020)

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain
por: Auyeung, Andrew, et al.
Publicado: (2023)

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity
por: Staats Pires, Ananda, et al.
Publicado: (2020)

PPARs and the Kynurenine Pathway in Melanoma—Potential Biological Interactions
por: Walczak, Katarzyna, et al.
Publicado: (2023)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022)

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2015)

Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
por: Sadok, Ilona, et al.
Publicado: (2021)

Potential drug targets in the kynurenine pathway to treat acute schizophrenia
por: Malhotra, Ayush, et al.
Publicado: (2021)

Major Developments in the Design of Inhibitors along the Kynurenine Pathway
por: Jacobs, Kelly R., et al.
Publicado: (2017)

The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy
por: Zychowska, Magdalena, et al.
Publicado: (2015)

CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
por: Bogacka, Joanna, et al.
Publicado: (2022)

Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions
por: Jovanovic, Filip, et al.
Publicado: (2023)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019)

New Perspective on Anorexia Nervosa: Tryptophan-Kynurenine Pathway Hypothesis
por: Alberts, Charl, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_funldfamfgn21821uppakoa4dk