Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3

Aphrocallistes vastus lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cer...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Jiajun, Feng, Hualin, Xu, Xiang, Liu, Tingting, Ye, Ting, Chen, Kan, Li, Gongchu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537278/
https://www.ncbi.nlm.nih.gov/pubmed/34677432
http://dx.doi.org/10.3390/md19100532
_version_ 1784588212018085888
author Ni, Jiajun
Feng, Hualin
Xu, Xiang
Liu, Tingting
Ye, Ting
Chen, Kan
Li, Gongchu
author_facet Ni, Jiajun
Feng, Hualin
Xu, Xiang
Liu, Tingting
Ye, Ting
Chen, Kan
Li, Gongchu
author_sort Ni, Jiajun
collection PubMed
description Aphrocallistes vastus lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL.
format Online
Article
Text
id pubmed-8537278
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85372782021-10-24 Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 Ni, Jiajun Feng, Hualin Xu, Xiang Liu, Tingting Ye, Ting Chen, Kan Li, Gongchu Mar Drugs Article Aphrocallistes vastus lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL. MDPI 2021-09-23 /pmc/articles/PMC8537278/ /pubmed/34677432 http://dx.doi.org/10.3390/md19100532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ni, Jiajun
Feng, Hualin
Xu, Xiang
Liu, Tingting
Ye, Ting
Chen, Kan
Li, Gongchu
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title_full Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title_fullStr Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title_full_unstemmed Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title_short Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
title_sort oncolytic vaccinia virus harboring aphrocallistes vastus lectin inhibits the growth of cervical cancer cells hela s3
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537278/
https://www.ncbi.nlm.nih.gov/pubmed/34677432
http://dx.doi.org/10.3390/md19100532
work_keys_str_mv AT nijiajun oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT fenghualin oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT xuxiang oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT liutingting oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT yeting oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT chenkan oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3
AT ligongchu oncolyticvacciniavirusharboringaphrocallistesvastuslectininhibitsthegrowthofcervicalcancercellshelas3

Ejemplares similares