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Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis

There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posteri...

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Autores principales: Martucci, Alessio, Landi, Doriana, Cesareo, Massimo, Di Carlo, Emiliano, Di Mauro, Giovanni, Sorge, Roberto Pietro, Albanese, Maria, Gabri Nicoletti, Carolina, Mataluni, Giorgia, Mercuri, Nicola Biagio, Di Marino, Matteo, Aiello, Francesco, Centonze, Diego, Nucci, Carlo, Marfia, Girolama Alessandra, Mancino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537290/
https://www.ncbi.nlm.nih.gov/pubmed/34682817
http://dx.doi.org/10.3390/jcm10204693
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author Martucci, Alessio
Landi, Doriana
Cesareo, Massimo
Di Carlo, Emiliano
Di Mauro, Giovanni
Sorge, Roberto Pietro
Albanese, Maria
Gabri Nicoletti, Carolina
Mataluni, Giorgia
Mercuri, Nicola Biagio
Di Marino, Matteo
Aiello, Francesco
Centonze, Diego
Nucci, Carlo
Marfia, Girolama Alessandra
Mancino, Raffaele
author_facet Martucci, Alessio
Landi, Doriana
Cesareo, Massimo
Di Carlo, Emiliano
Di Mauro, Giovanni
Sorge, Roberto Pietro
Albanese, Maria
Gabri Nicoletti, Carolina
Mataluni, Giorgia
Mercuri, Nicola Biagio
Di Marino, Matteo
Aiello, Francesco
Centonze, Diego
Nucci, Carlo
Marfia, Girolama Alessandra
Mancino, Raffaele
author_sort Martucci, Alessio
collection PubMed
description There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult.
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spelling pubmed-85372902021-10-24 Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis Martucci, Alessio Landi, Doriana Cesareo, Massimo Di Carlo, Emiliano Di Mauro, Giovanni Sorge, Roberto Pietro Albanese, Maria Gabri Nicoletti, Carolina Mataluni, Giorgia Mercuri, Nicola Biagio Di Marino, Matteo Aiello, Francesco Centonze, Diego Nucci, Carlo Marfia, Girolama Alessandra Mancino, Raffaele J Clin Med Article There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult. MDPI 2021-10-13 /pmc/articles/PMC8537290/ /pubmed/34682817 http://dx.doi.org/10.3390/jcm10204693 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martucci, Alessio
Landi, Doriana
Cesareo, Massimo
Di Carlo, Emiliano
Di Mauro, Giovanni
Sorge, Roberto Pietro
Albanese, Maria
Gabri Nicoletti, Carolina
Mataluni, Giorgia
Mercuri, Nicola Biagio
Di Marino, Matteo
Aiello, Francesco
Centonze, Diego
Nucci, Carlo
Marfia, Girolama Alessandra
Mancino, Raffaele
Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title_full Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title_fullStr Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title_full_unstemmed Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title_short Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
title_sort complex rearrangement of the entire retinal posterior pole in patients with relapsing remitting multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537290/
https://www.ncbi.nlm.nih.gov/pubmed/34682817
http://dx.doi.org/10.3390/jcm10204693
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