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Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posteri...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537290/ https://www.ncbi.nlm.nih.gov/pubmed/34682817 http://dx.doi.org/10.3390/jcm10204693 |
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author | Martucci, Alessio Landi, Doriana Cesareo, Massimo Di Carlo, Emiliano Di Mauro, Giovanni Sorge, Roberto Pietro Albanese, Maria Gabri Nicoletti, Carolina Mataluni, Giorgia Mercuri, Nicola Biagio Di Marino, Matteo Aiello, Francesco Centonze, Diego Nucci, Carlo Marfia, Girolama Alessandra Mancino, Raffaele |
author_facet | Martucci, Alessio Landi, Doriana Cesareo, Massimo Di Carlo, Emiliano Di Mauro, Giovanni Sorge, Roberto Pietro Albanese, Maria Gabri Nicoletti, Carolina Mataluni, Giorgia Mercuri, Nicola Biagio Di Marino, Matteo Aiello, Francesco Centonze, Diego Nucci, Carlo Marfia, Girolama Alessandra Mancino, Raffaele |
author_sort | Martucci, Alessio |
collection | PubMed |
description | There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult. |
format | Online Article Text |
id | pubmed-8537290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85372902021-10-24 Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis Martucci, Alessio Landi, Doriana Cesareo, Massimo Di Carlo, Emiliano Di Mauro, Giovanni Sorge, Roberto Pietro Albanese, Maria Gabri Nicoletti, Carolina Mataluni, Giorgia Mercuri, Nicola Biagio Di Marino, Matteo Aiello, Francesco Centonze, Diego Nucci, Carlo Marfia, Girolama Alessandra Mancino, Raffaele J Clin Med Article There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult. MDPI 2021-10-13 /pmc/articles/PMC8537290/ /pubmed/34682817 http://dx.doi.org/10.3390/jcm10204693 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martucci, Alessio Landi, Doriana Cesareo, Massimo Di Carlo, Emiliano Di Mauro, Giovanni Sorge, Roberto Pietro Albanese, Maria Gabri Nicoletti, Carolina Mataluni, Giorgia Mercuri, Nicola Biagio Di Marino, Matteo Aiello, Francesco Centonze, Diego Nucci, Carlo Marfia, Girolama Alessandra Mancino, Raffaele Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title_full | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title_fullStr | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title_full_unstemmed | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title_short | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
title_sort | complex rearrangement of the entire retinal posterior pole in patients with relapsing remitting multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537290/ https://www.ncbi.nlm.nih.gov/pubmed/34682817 http://dx.doi.org/10.3390/jcm10204693 |
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