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Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537324/ https://www.ncbi.nlm.nih.gov/pubmed/34696263 http://dx.doi.org/10.3390/vaccines9101155 |
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author | Guan, Li-Jun Song, Ji-Jian Xue, Yun Ai, Xia Liu, Zhi-Jun Si, Li-Fang Li, Meng-Yun Zhao, Zhan-Qin |
author_facet | Guan, Li-Jun Song, Ji-Jian Xue, Yun Ai, Xia Liu, Zhi-Jun Si, Li-Fang Li, Meng-Yun Zhao, Zhan-Qin |
author_sort | Guan, Li-Jun |
collection | PubMed |
description | Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model. |
format | Online Article Text |
id | pubmed-8537324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85373242021-10-24 Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice Guan, Li-Jun Song, Ji-Jian Xue, Yun Ai, Xia Liu, Zhi-Jun Si, Li-Fang Li, Meng-Yun Zhao, Zhan-Qin Vaccines (Basel) Article Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model. MDPI 2021-10-09 /pmc/articles/PMC8537324/ /pubmed/34696263 http://dx.doi.org/10.3390/vaccines9101155 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guan, Li-Jun Song, Ji-Jian Xue, Yun Ai, Xia Liu, Zhi-Jun Si, Li-Fang Li, Meng-Yun Zhao, Zhan-Qin Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title | Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title_full | Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title_fullStr | Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title_full_unstemmed | Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title_short | Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice |
title_sort | immune protective efficacy of china’s traditional inactivated and attenuated vaccines against the prevalent strains of pasteurella multocida in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537324/ https://www.ncbi.nlm.nih.gov/pubmed/34696263 http://dx.doi.org/10.3390/vaccines9101155 |
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