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Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice

Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO...

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Autores principales: Guan, Li-Jun, Song, Ji-Jian, Xue, Yun, Ai, Xia, Liu, Zhi-Jun, Si, Li-Fang, Li, Meng-Yun, Zhao, Zhan-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537324/
https://www.ncbi.nlm.nih.gov/pubmed/34696263
http://dx.doi.org/10.3390/vaccines9101155
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author Guan, Li-Jun
Song, Ji-Jian
Xue, Yun
Ai, Xia
Liu, Zhi-Jun
Si, Li-Fang
Li, Meng-Yun
Zhao, Zhan-Qin
author_facet Guan, Li-Jun
Song, Ji-Jian
Xue, Yun
Ai, Xia
Liu, Zhi-Jun
Si, Li-Fang
Li, Meng-Yun
Zhao, Zhan-Qin
author_sort Guan, Li-Jun
collection PubMed
description Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model.
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spelling pubmed-85373242021-10-24 Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice Guan, Li-Jun Song, Ji-Jian Xue, Yun Ai, Xia Liu, Zhi-Jun Si, Li-Fang Li, Meng-Yun Zhao, Zhan-Qin Vaccines (Basel) Article Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model. MDPI 2021-10-09 /pmc/articles/PMC8537324/ /pubmed/34696263 http://dx.doi.org/10.3390/vaccines9101155 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guan, Li-Jun
Song, Ji-Jian
Xue, Yun
Ai, Xia
Liu, Zhi-Jun
Si, Li-Fang
Li, Meng-Yun
Zhao, Zhan-Qin
Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title_full Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title_fullStr Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title_full_unstemmed Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title_short Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice
title_sort immune protective efficacy of china’s traditional inactivated and attenuated vaccines against the prevalent strains of pasteurella multocida in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537324/
https://www.ncbi.nlm.nih.gov/pubmed/34696263
http://dx.doi.org/10.3390/vaccines9101155
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