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Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin
Candida auris readily colonizes skin and efficiently spreads among patients in healthcare settings worldwide. Given the capacity of this drug-resistant fungal pathogen to cause invasive disease with high mortality, hospitals frequently employ chlorhexidine bathing to reduce skin colonization. Using...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537331/ https://www.ncbi.nlm.nih.gov/pubmed/34682225 http://dx.doi.org/10.3390/jof7100804 |
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author | Johnson, Chad J. Eix, Emily F. Lam, Brandon C. Wartman, Kayla M. Meudt, Jennifer J. Shanmuganayagam, Dhanansayan Nett, Jeniel E. |
author_facet | Johnson, Chad J. Eix, Emily F. Lam, Brandon C. Wartman, Kayla M. Meudt, Jennifer J. Shanmuganayagam, Dhanansayan Nett, Jeniel E. |
author_sort | Johnson, Chad J. |
collection | PubMed |
description | Candida auris readily colonizes skin and efficiently spreads among patients in healthcare settings worldwide. Given the capacity of this drug-resistant fungal pathogen to cause invasive disease with high mortality, hospitals frequently employ chlorhexidine bathing to reduce skin colonization. Using an ex vivo skin model, we show only a mild reduction in C. auris following chlorhexidine application. This finding helps explain why chlorhexidine bathing may have failures clinically, despite potent in vitro activity. We further show that isopropanol augments the activity of chlorhexidine against C. auris on skin. Additionally, we find both tea tree (Melaleuca alternifolia) oil and lemongrass (Cymbopogon flexuosus) oil to further enhance the activity of chlorhexidine/isopropanol for decolonization. We link this antifungal activity to individual oil components and show how some of these components act synergistically with chlorhexidine/isopropanol. Together, the studies provide strategies to improve C. auris skin decolonization through the incorporation of commonly used topical compounds. |
format | Online Article Text |
id | pubmed-8537331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85373312021-10-24 Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin Johnson, Chad J. Eix, Emily F. Lam, Brandon C. Wartman, Kayla M. Meudt, Jennifer J. Shanmuganayagam, Dhanansayan Nett, Jeniel E. J Fungi (Basel) Article Candida auris readily colonizes skin and efficiently spreads among patients in healthcare settings worldwide. Given the capacity of this drug-resistant fungal pathogen to cause invasive disease with high mortality, hospitals frequently employ chlorhexidine bathing to reduce skin colonization. Using an ex vivo skin model, we show only a mild reduction in C. auris following chlorhexidine application. This finding helps explain why chlorhexidine bathing may have failures clinically, despite potent in vitro activity. We further show that isopropanol augments the activity of chlorhexidine against C. auris on skin. Additionally, we find both tea tree (Melaleuca alternifolia) oil and lemongrass (Cymbopogon flexuosus) oil to further enhance the activity of chlorhexidine/isopropanol for decolonization. We link this antifungal activity to individual oil components and show how some of these components act synergistically with chlorhexidine/isopropanol. Together, the studies provide strategies to improve C. auris skin decolonization through the incorporation of commonly used topical compounds. MDPI 2021-09-25 /pmc/articles/PMC8537331/ /pubmed/34682225 http://dx.doi.org/10.3390/jof7100804 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Johnson, Chad J. Eix, Emily F. Lam, Brandon C. Wartman, Kayla M. Meudt, Jennifer J. Shanmuganayagam, Dhanansayan Nett, Jeniel E. Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title | Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title_full | Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title_fullStr | Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title_full_unstemmed | Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title_short | Augmenting the Activity of Chlorhexidine for Decolonization of Candida auris from Porcine skin |
title_sort | augmenting the activity of chlorhexidine for decolonization of candida auris from porcine skin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537331/ https://www.ncbi.nlm.nih.gov/pubmed/34682225 http://dx.doi.org/10.3390/jof7100804 |
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