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Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea

Neurological diseases in cattle can be caused by several infectious agents. Astroviruses are increasingly recognized as the causative agent of encephalitis in various animals, including humans. In this study, a neuroinvasive astrovirus (BoAstV 20B05) was discovered in the brain tissues of an 81-mont...

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Autores principales: Lee, Sook-Young, Kim, Jong-Ho, Kim, Yoon-Ji, Kim, Young-Sik, Roh, Su-Gwon, Lee, Kyung-Hyun, Kim, Heui-Jin, Shin, Jae-Ho, Oem, Jae-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537357/
https://www.ncbi.nlm.nih.gov/pubmed/34696371
http://dx.doi.org/10.3390/v13101941
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author Lee, Sook-Young
Kim, Jong-Ho
Kim, Yoon-Ji
Kim, Young-Sik
Roh, Su-Gwon
Lee, Kyung-Hyun
Kim, Heui-Jin
Shin, Jae-Ho
Oem, Jae-Ku
author_facet Lee, Sook-Young
Kim, Jong-Ho
Kim, Yoon-Ji
Kim, Young-Sik
Roh, Su-Gwon
Lee, Kyung-Hyun
Kim, Heui-Jin
Shin, Jae-Ho
Oem, Jae-Ku
author_sort Lee, Sook-Young
collection PubMed
description Neurological diseases in cattle can be caused by several infectious agents. Astroviruses are increasingly recognized as the causative agent of encephalitis in various animals, including humans. In this study, a neuroinvasive astrovirus (BoAstV 20B05) was discovered in the brain tissues of an 81-month-old Korean native cattle with neurological symptoms. Lymphocyte infiltration and multifocal perivascular cuffing were observed in the cerebrum and brain stem, and viral antigens were also detected in the meninges. In particular, the concentration of the astroviral genome was high in the brain tissues. Korean BoAstV 20B05 was classified into the CH13/NeuroS1 clade and was closely related to the Neuro-Uy and KagoshimaSR28-462 strains. Our evolutionary analysis showed that Korean BoAstV 20B05 belongs to the sub-lineage NeuroS1 and evolved independently of BoAstV KagoshimaSR28-462. These results suggest that neuroinvasive astroviruses were first introduced in Korea. However, analysis is limited by the lack of reference astrovirus sequences reported in various countries within Asia, and further analysis should be performed using more strains. In this study, we identified a neuroinvasive astrovirus infection with neurological symptoms for the first time in South Korea and confirmed that BoAstV 20B05 may have been introduced in South Korea a long time ago.
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spelling pubmed-85373572021-10-24 Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea Lee, Sook-Young Kim, Jong-Ho Kim, Yoon-Ji Kim, Young-Sik Roh, Su-Gwon Lee, Kyung-Hyun Kim, Heui-Jin Shin, Jae-Ho Oem, Jae-Ku Viruses Brief Report Neurological diseases in cattle can be caused by several infectious agents. Astroviruses are increasingly recognized as the causative agent of encephalitis in various animals, including humans. In this study, a neuroinvasive astrovirus (BoAstV 20B05) was discovered in the brain tissues of an 81-month-old Korean native cattle with neurological symptoms. Lymphocyte infiltration and multifocal perivascular cuffing were observed in the cerebrum and brain stem, and viral antigens were also detected in the meninges. In particular, the concentration of the astroviral genome was high in the brain tissues. Korean BoAstV 20B05 was classified into the CH13/NeuroS1 clade and was closely related to the Neuro-Uy and KagoshimaSR28-462 strains. Our evolutionary analysis showed that Korean BoAstV 20B05 belongs to the sub-lineage NeuroS1 and evolved independently of BoAstV KagoshimaSR28-462. These results suggest that neuroinvasive astroviruses were first introduced in Korea. However, analysis is limited by the lack of reference astrovirus sequences reported in various countries within Asia, and further analysis should be performed using more strains. In this study, we identified a neuroinvasive astrovirus infection with neurological symptoms for the first time in South Korea and confirmed that BoAstV 20B05 may have been introduced in South Korea a long time ago. MDPI 2021-09-28 /pmc/articles/PMC8537357/ /pubmed/34696371 http://dx.doi.org/10.3390/v13101941 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Lee, Sook-Young
Kim, Jong-Ho
Kim, Yoon-Ji
Kim, Young-Sik
Roh, Su-Gwon
Lee, Kyung-Hyun
Kim, Heui-Jin
Shin, Jae-Ho
Oem, Jae-Ku
Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title_full Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title_fullStr Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title_full_unstemmed Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title_short Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea
title_sort astrovirus infection in cattle with nonsuppurative meningoencephalitis in south korea
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537357/
https://www.ncbi.nlm.nih.gov/pubmed/34696371
http://dx.doi.org/10.3390/v13101941
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