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Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factor...

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Detalles Bibliográficos
Autores principales: Kourtidou, Christodoula, Stangou, Maria, Marinaki, Smaragdi, Tziomalos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537513/
https://www.ncbi.nlm.nih.gov/pubmed/34681856
http://dx.doi.org/10.3390/ijms222011196
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author Kourtidou, Christodoula
Stangou, Maria
Marinaki, Smaragdi
Tziomalos, Konstantinos
author_facet Kourtidou, Christodoula
Stangou, Maria
Marinaki, Smaragdi
Tziomalos, Konstantinos
author_sort Kourtidou, Christodoula
collection PubMed
description Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors.
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spelling pubmed-85375132021-10-24 Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease Kourtidou, Christodoula Stangou, Maria Marinaki, Smaragdi Tziomalos, Konstantinos Int J Mol Sci Review Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors. MDPI 2021-10-17 /pmc/articles/PMC8537513/ /pubmed/34681856 http://dx.doi.org/10.3390/ijms222011196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kourtidou, Christodoula
Stangou, Maria
Marinaki, Smaragdi
Tziomalos, Konstantinos
Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title_full Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title_fullStr Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title_full_unstemmed Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title_short Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
title_sort novel cardiovascular risk factors in patients with diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537513/
https://www.ncbi.nlm.nih.gov/pubmed/34681856
http://dx.doi.org/10.3390/ijms222011196
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