Cargando…
Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease
Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factor...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537513/ https://www.ncbi.nlm.nih.gov/pubmed/34681856 http://dx.doi.org/10.3390/ijms222011196 |
_version_ | 1784588278587981824 |
---|---|
author | Kourtidou, Christodoula Stangou, Maria Marinaki, Smaragdi Tziomalos, Konstantinos |
author_facet | Kourtidou, Christodoula Stangou, Maria Marinaki, Smaragdi Tziomalos, Konstantinos |
author_sort | Kourtidou, Christodoula |
collection | PubMed |
description | Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors. |
format | Online Article Text |
id | pubmed-8537513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85375132021-10-24 Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease Kourtidou, Christodoula Stangou, Maria Marinaki, Smaragdi Tziomalos, Konstantinos Int J Mol Sci Review Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors. MDPI 2021-10-17 /pmc/articles/PMC8537513/ /pubmed/34681856 http://dx.doi.org/10.3390/ijms222011196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kourtidou, Christodoula Stangou, Maria Marinaki, Smaragdi Tziomalos, Konstantinos Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title | Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title_full | Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title_fullStr | Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title_full_unstemmed | Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title_short | Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease |
title_sort | novel cardiovascular risk factors in patients with diabetic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537513/ https://www.ncbi.nlm.nih.gov/pubmed/34681856 http://dx.doi.org/10.3390/ijms222011196 |
work_keys_str_mv | AT kourtidouchristodoula novelcardiovascularriskfactorsinpatientswithdiabetickidneydisease AT stangoumaria novelcardiovascularriskfactorsinpatientswithdiabetickidneydisease AT marinakismaragdi novelcardiovascularriskfactorsinpatientswithdiabetickidneydisease AT tziomaloskonstantinos novelcardiovascularriskfactorsinpatientswithdiabetickidneydisease |