Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the ke...

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Detalles Bibliográficos
Autores principales: Martens, Colton R., Accornero, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537553/
https://www.ncbi.nlm.nih.gov/pubmed/34696354
http://dx.doi.org/10.3390/v13101924
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author Martens, Colton R.
Accornero, Federica
author_facet Martens, Colton R.
Accornero, Federica
author_sort Martens, Colton R.
collection PubMed
description Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy.
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spelling pubmed-85375532021-10-24 Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure Martens, Colton R. Accornero, Federica Viruses Review Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy. MDPI 2021-09-24 /pmc/articles/PMC8537553/ /pubmed/34696354 http://dx.doi.org/10.3390/v13101924 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martens, Colton R.
Accornero, Federica
Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title_full Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title_fullStr Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title_full_unstemmed Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title_short Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure
title_sort viruses in the heart: direct and indirect routes to myocarditis and heart failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537553/
https://www.ncbi.nlm.nih.gov/pubmed/34696354
http://dx.doi.org/10.3390/v13101924
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