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Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy
The widespread increase in multiple severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants is causing a significant health concern in the United States and worldwide. These variants exhibit increased transmissibility, cause more severe disease, exhibit evasive immune properties, impai...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537675/ https://www.ncbi.nlm.nih.gov/pubmed/34696303 http://dx.doi.org/10.3390/vaccines9101195 |
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author | Ramesh, Sindhu Govindarajulu, Manoj Parise, Rachel S. Neel, Logan Shankar, Tharanath Patel, Shriya Lowery, Payton Smith, Forrest Dhanasekaran, Muralikrishnan Moore, Timothy |
author_facet | Ramesh, Sindhu Govindarajulu, Manoj Parise, Rachel S. Neel, Logan Shankar, Tharanath Patel, Shriya Lowery, Payton Smith, Forrest Dhanasekaran, Muralikrishnan Moore, Timothy |
author_sort | Ramesh, Sindhu |
collection | PubMed |
description | The widespread increase in multiple severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants is causing a significant health concern in the United States and worldwide. These variants exhibit increased transmissibility, cause more severe disease, exhibit evasive immune properties, impair neutralization by antibodies from vaccinated individuals or convalescence sera, and reinfection. The Centers for Disease Control and Prevention (CDC) has classified SARS-CoV-2 variants into variants of interest, variants of concern, and variants of high consequence. Currently, four variants of concern (B.1.1.7, B.1.351, P.1, and B.1.617.2) and several variants of interests (B.1.526, B.1.525, and P.2) are characterized and are essential for close monitoring. In this review, we discuss the different SARS-CoV-2 variants, emphasizing variants of concern circulating the world and highlight the various mutations and how these mutations affect the characteristics of the virus. In addition, we discuss the most common vaccines and the various studies concerning the efficacy of these vaccines against different variants of concern. |
format | Online Article Text |
id | pubmed-8537675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85376752021-10-24 Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy Ramesh, Sindhu Govindarajulu, Manoj Parise, Rachel S. Neel, Logan Shankar, Tharanath Patel, Shriya Lowery, Payton Smith, Forrest Dhanasekaran, Muralikrishnan Moore, Timothy Vaccines (Basel) Review The widespread increase in multiple severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants is causing a significant health concern in the United States and worldwide. These variants exhibit increased transmissibility, cause more severe disease, exhibit evasive immune properties, impair neutralization by antibodies from vaccinated individuals or convalescence sera, and reinfection. The Centers for Disease Control and Prevention (CDC) has classified SARS-CoV-2 variants into variants of interest, variants of concern, and variants of high consequence. Currently, four variants of concern (B.1.1.7, B.1.351, P.1, and B.1.617.2) and several variants of interests (B.1.526, B.1.525, and P.2) are characterized and are essential for close monitoring. In this review, we discuss the different SARS-CoV-2 variants, emphasizing variants of concern circulating the world and highlight the various mutations and how these mutations affect the characteristics of the virus. In addition, we discuss the most common vaccines and the various studies concerning the efficacy of these vaccines against different variants of concern. MDPI 2021-10-18 /pmc/articles/PMC8537675/ /pubmed/34696303 http://dx.doi.org/10.3390/vaccines9101195 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ramesh, Sindhu Govindarajulu, Manoj Parise, Rachel S. Neel, Logan Shankar, Tharanath Patel, Shriya Lowery, Payton Smith, Forrest Dhanasekaran, Muralikrishnan Moore, Timothy Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title | Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title_full | Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title_fullStr | Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title_full_unstemmed | Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title_short | Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine Efficacy |
title_sort | emerging sars-cov-2 variants: a review of its mutations, its implications and vaccine efficacy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537675/ https://www.ncbi.nlm.nih.gov/pubmed/34696303 http://dx.doi.org/10.3390/vaccines9101195 |
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