Cargando…

A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study

Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study in...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciudin, Andreea, Fidilio, Enzamaría, Gutiérrez-Carrasquilla, Liliana, Caixàs, Assumpta, Vilarrasa, Núria, Pellitero, Silvia, Simó-Servat, Andreu, Vilallonga, Ramon, Ruiz, Amador, de la Fuente, Maricruz, Luna, Alexis, Sánchez, Enric, Rigla, Mercedes, Hernández, Cristina, Salas, Eduardo, Simó, Rafael, Lecube, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537695/
https://www.ncbi.nlm.nih.gov/pubmed/34683180
http://dx.doi.org/10.3390/jpm11101040
_version_ 1784588323214327808
author Ciudin, Andreea
Fidilio, Enzamaría
Gutiérrez-Carrasquilla, Liliana
Caixàs, Assumpta
Vilarrasa, Núria
Pellitero, Silvia
Simó-Servat, Andreu
Vilallonga, Ramon
Ruiz, Amador
de la Fuente, Maricruz
Luna, Alexis
Sánchez, Enric
Rigla, Mercedes
Hernández, Cristina
Salas, Eduardo
Simó, Rafael
Lecube, Albert
author_facet Ciudin, Andreea
Fidilio, Enzamaría
Gutiérrez-Carrasquilla, Liliana
Caixàs, Assumpta
Vilarrasa, Núria
Pellitero, Silvia
Simó-Servat, Andreu
Vilallonga, Ramon
Ruiz, Amador
de la Fuente, Maricruz
Luna, Alexis
Sánchez, Enric
Rigla, Mercedes
Hernández, Cristina
Salas, Eduardo
Simó, Rafael
Lecube, Albert
author_sort Ciudin, Andreea
collection PubMed
description Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice.
format Online
Article
Text
id pubmed-8537695
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85376952021-10-24 A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study Ciudin, Andreea Fidilio, Enzamaría Gutiérrez-Carrasquilla, Liliana Caixàs, Assumpta Vilarrasa, Núria Pellitero, Silvia Simó-Servat, Andreu Vilallonga, Ramon Ruiz, Amador de la Fuente, Maricruz Luna, Alexis Sánchez, Enric Rigla, Mercedes Hernández, Cristina Salas, Eduardo Simó, Rafael Lecube, Albert J Pers Med Article Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. MDPI 2021-10-17 /pmc/articles/PMC8537695/ /pubmed/34683180 http://dx.doi.org/10.3390/jpm11101040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ciudin, Andreea
Fidilio, Enzamaría
Gutiérrez-Carrasquilla, Liliana
Caixàs, Assumpta
Vilarrasa, Núria
Pellitero, Silvia
Simó-Servat, Andreu
Vilallonga, Ramon
Ruiz, Amador
de la Fuente, Maricruz
Luna, Alexis
Sánchez, Enric
Rigla, Mercedes
Hernández, Cristina
Salas, Eduardo
Simó, Rafael
Lecube, Albert
A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title_full A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title_fullStr A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title_full_unstemmed A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title_short A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
title_sort clinical-genetic score for predicting weight loss after bariatric surgery: the obegen study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537695/
https://www.ncbi.nlm.nih.gov/pubmed/34683180
http://dx.doi.org/10.3390/jpm11101040
work_keys_str_mv AT ciudinandreea aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT fidilioenzamaria aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT gutierrezcarrasquillaliliana aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT caixasassumpta aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT vilarrasanuria aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT pelliterosilvia aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT simoservatandreu aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT vilallongaramon aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT ruizamador aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT delafuentemaricruz aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT lunaalexis aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT sanchezenric aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT riglamercedes aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT hernandezcristina aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT salaseduardo aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT simorafael aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT lecubealbert aclinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT ciudinandreea clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT fidilioenzamaria clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT gutierrezcarrasquillaliliana clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT caixasassumpta clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT vilarrasanuria clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT pelliterosilvia clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT simoservatandreu clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT vilallongaramon clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT ruizamador clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT delafuentemaricruz clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT lunaalexis clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT sanchezenric clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT riglamercedes clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT hernandezcristina clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT salaseduardo clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT simorafael clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy
AT lecubealbert clinicalgeneticscoreforpredictingweightlossafterbariatricsurgerytheobegenstudy