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A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study in...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537695/ https://www.ncbi.nlm.nih.gov/pubmed/34683180 http://dx.doi.org/10.3390/jpm11101040 |
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author | Ciudin, Andreea Fidilio, Enzamaría Gutiérrez-Carrasquilla, Liliana Caixàs, Assumpta Vilarrasa, Núria Pellitero, Silvia Simó-Servat, Andreu Vilallonga, Ramon Ruiz, Amador de la Fuente, Maricruz Luna, Alexis Sánchez, Enric Rigla, Mercedes Hernández, Cristina Salas, Eduardo Simó, Rafael Lecube, Albert |
author_facet | Ciudin, Andreea Fidilio, Enzamaría Gutiérrez-Carrasquilla, Liliana Caixàs, Assumpta Vilarrasa, Núria Pellitero, Silvia Simó-Servat, Andreu Vilallonga, Ramon Ruiz, Amador de la Fuente, Maricruz Luna, Alexis Sánchez, Enric Rigla, Mercedes Hernández, Cristina Salas, Eduardo Simó, Rafael Lecube, Albert |
author_sort | Ciudin, Andreea |
collection | PubMed |
description | Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. |
format | Online Article Text |
id | pubmed-8537695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85376952021-10-24 A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study Ciudin, Andreea Fidilio, Enzamaría Gutiérrez-Carrasquilla, Liliana Caixàs, Assumpta Vilarrasa, Núria Pellitero, Silvia Simó-Servat, Andreu Vilallonga, Ramon Ruiz, Amador de la Fuente, Maricruz Luna, Alexis Sánchez, Enric Rigla, Mercedes Hernández, Cristina Salas, Eduardo Simó, Rafael Lecube, Albert J Pers Med Article Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. MDPI 2021-10-17 /pmc/articles/PMC8537695/ /pubmed/34683180 http://dx.doi.org/10.3390/jpm11101040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ciudin, Andreea Fidilio, Enzamaría Gutiérrez-Carrasquilla, Liliana Caixàs, Assumpta Vilarrasa, Núria Pellitero, Silvia Simó-Servat, Andreu Vilallonga, Ramon Ruiz, Amador de la Fuente, Maricruz Luna, Alexis Sánchez, Enric Rigla, Mercedes Hernández, Cristina Salas, Eduardo Simó, Rafael Lecube, Albert A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title | A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title_full | A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title_fullStr | A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title_full_unstemmed | A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title_short | A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study |
title_sort | clinical-genetic score for predicting weight loss after bariatric surgery: the obegen study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537695/ https://www.ncbi.nlm.nih.gov/pubmed/34683180 http://dx.doi.org/10.3390/jpm11101040 |
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