Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4

Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ligands by HDAC4. For this purpose, a structure acti...

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Detalles Bibliográficos
Autores principales: Schweipert, Markus, Jänsch, Niklas, Upadhyay, Neha, Tilekar, Kalpana, Wozny, Ewelina, Basheer, Sidra, Wurster, Eva, Müller, Marlene, C S, Ramaa, Meyer-Almes, Franz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537711/
https://www.ncbi.nlm.nih.gov/pubmed/34681256
http://dx.doi.org/10.3390/ph14101032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537711/
https://www.ncbi.nlm.nih.gov/pubmed/34681256
http://dx.doi.org/10.3390/ph14101032

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